ChemicalBook > CAS DataBase List > DM3-Sme
DM3-Sme
- Product Name
- DM3-Sme
- CAS No.
- 796073-70-6
- Chemical Name
- DM3-Sme
- Synonyms
- DM3-Sme;Maytansine, N2'-deacetyl-N2'-[4-(methyldithio)-1-oxopentyl]- (9CI)
- CBNumber
- CB23959871
- Molecular Formula
- C38H54ClN3O10S2
- Formula Weight
- 812.43
- MOL File
- 796073-70-6.mol
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DM3-Sme Property
- Boiling point:
- 962.6±65.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 9.82±0.70(Predicted)
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0104944
- Product name
- DM3-SMe
- Packaging
- 100mg
- Price
- $4138
- Updated
- 2021/12/16
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DM3-Sme Chemical Properties,Usage,Production
Description
DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2].
References
[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). [2]. Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-Science.
DM3-Sme Preparation Products And Raw materials
Raw materials
Preparation Products
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DM3-Sme Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19892
- Advantage
- 58
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
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