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DM3-Sme

Product Name
DM3-Sme
CAS No.
796073-70-6
Chemical Name
DM3-Sme
Synonyms
DM3-Sme;Maytansine, N2'-deacetyl-N2'-[4-(methyldithio)-1-oxopentyl]- (9CI)
CBNumber
CB23959871
Molecular Formula
C38H54ClN3O10S2
Formula Weight
812.43
MOL File
796073-70-6.mol
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DM3-Sme Property

Boiling point:
962.6±65.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
9.82±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0104944
Product name
DM3-SMe
Packaging
100mg
Price
$4138
Updated
2021/12/16
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DM3-Sme Chemical Properties,Usage,Production

Description

DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2].

References

[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). [2]. Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-‎Science.

DM3-Sme Preparation Products And Raw materials

Raw materials

Preparation Products

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DM3-Sme Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58

796073-70-6, DM3-SmeRelated Search:


  • DM3-Sme
  • Maytansine, N2'-deacetyl-N2'-[4-(methyldithio)-1-oxopentyl]- (9CI)
  • 796073-70-6
  • C38H54ClN3O10S2