ChemicalBook > CAS DataBase List > ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE

ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE

Product Name
ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE
CAS No.
76360-82-2
Chemical Name
ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE
Synonyms
NSC 165300;-2-(methylsulfanyl);Ethyl 4-(methylamino);-5-pyrimidinecarboxylate;Ethyl 4-(MethylaMino)-2-(Methylthio)pyriMidine-5-carboxylate;ethyl 2-(Methylthio)-4-(MethylaMino)-pyriMidine-5-carboxylate;2-(Methylthio)-4-(MethylaMino)-pyriMidine-5-carboxylic acid e;ethyl 4-(MethylaMino)-2-(Methylsulfanyl)pyriMidine-5-carboxylate;ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE;4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxylic Acid Ethyl Ester
CBNumber
CB2401092
Molecular Formula
C9H13N3O2S
Formula Weight
227.28
MOL File
76360-82-2.mol
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ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE Property

Melting point:
91-93 °C
Boiling point:
368.9±22.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform, Dichloromethane, DMSO, Ethyl Acetate, Methanol
pka
3.11±0.10(Predicted)
form 
Solid
color 
White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M286905
Product name
4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxylicAcidEthylEster
Packaging
500mg
Price
$235
Updated
2021/12/16
TRC
Product number
M286905
Product name
4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxylicAcidEthylEster
Packaging
100mg
Price
$130
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0156236
Product name
ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE
Purity
95.00%
Packaging
250MG
Price
$739.2
Updated
2021/12/16
Matrix Scientific
Product number
132422
Product name
Ethyl4-(methylamino)-2-(methylthio)-pyrimidine-5-carboxylate
Purity
97%
Packaging
5g
Price
$1224
Updated
2021/12/16
Matrix Scientific
Product number
132422
Product name
Ethyl4-(methylamino)-2-(methylthio)-pyrimidine-5-carboxylate
Purity
97%
Packaging
10g
Price
$1764
Updated
2021/12/16
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ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

An intermediate in the preparation of antitumor agents, antiinflammatory agents and tyrosine kinase inhibitors

Synthesis

5909-24-0

74-89-5

76360-82-2

A 33% aqueous methylamine solution (17.5 mL, 140 mmol) was slowly added dropwise to a dichloromethane solution (120 mL) containing ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate (10.0 g, 43.1 mmol) at 0 °C. The reaction mixture was stirred at this temperature for 30 minutes. The reaction mixture was stirred at this temperature for 30 minutes. Subsequently, it was quenched by the addition of water (150 mL), the organic phase was separated and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure to afford the product ethyl 4-methylamino-2-methylthio-5-pyrimidinecarboxylate (9.77 g, 100% yield) as a white solid.

References

[1] Patent: WO2014/144737, 2014, A1. Location in patent: Paragraph 00719
[2] Patent: WO2015/19037, 2015, A1. Location in patent: Page/Page column 87; 88
[3] Patent: US2003/207900, 2003, A1. Location in patent: Page/Page column 15
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5439 - 5448
[5] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2255 - 2265

ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE Suppliers

Canada 1 China 73 India 3 Switzerland 1 United Kingdom 2 United States 6 Global 86
J & K SCIENTIFIC LTD.
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View Lastest Price from ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE manufacturers

Dideu Industries Group Limited
Product
ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE 76360-82-2
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-15
Career Henan Chemical Co
Product
ethyl 4-(methylamino)-2-methylsulfanylpyrimidine-5-carboxylate 76360-82-2
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-09

76360-82-2, ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATERelated Search:

ETHYL 4-(4-CHLOROANILINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 4-(BENZYLAMINO)-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE ETHYL 2-(METHYLSULFANYL)-4-(1-PYRROLIDINYL)-5-PYRIMIDINECARBOXYLATE ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 2-(METHYLSULFANYL)-4-MORPHOLINO-5-PYRIMIDINECARBOXYLATE ETHYL 2-(METHYLSULFANYL)-4-PIPERIDINO-5-PYRIMIDINECARBOXYLATE ETHYL 4-(3,4-DICHLOROANILINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE BUTTPARK 21\09-25 BUTTPARK 21\09-21 BUTTPARK 21\09-23 ETHYL 2-(METHYLSULFANYL)-4-[4-(TRIFLUOROMETHOXY)ANILINO]-5-PYRIMIDINECARBOXYLATE ETHYL 4-[(2-METHOXYETHYL)AMINO]-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE BUTTPARK 21\09-28 ETHYL 4-(DIMETHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 2-(METHYLSULFANYL)-4-[4-(TRIFLUOROMETHYL)ANILINO]-5-PYRIMIDINECARBOXYLATE ETHYL 4-[3,5-BIS(TRIFLUOROMETHYL)ANILINO]-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 4-[4-(2-FLUOROPHENYL)PIPERAZINO]-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 4-(ALLYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE

  • 4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxylic Acid Ethyl Ester
  • ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE
  • 4-MethylaMino-2-Methylsulfanyl-pyriMidine-5-carboxylic acid ethyl ester
  • ethyl 4-(MethylaMino)-2-(Methylsulfanyl)pyriMidine-5-carboxylate
  • Ethyl 4-(MethylaMino)-2-(Methylthio)pyriMidine-5-carboxylate
  • NSC 165300
  • 2-(Methylthio)-4-(MethylaMino)-pyriMidine-5-carboxylic acid e
  • ethyl 2-(Methylthio)-4-(MethylaMino)-pyriMidine-5-carboxylate
  • 5-Pyrimidinecarboxylic acid, 4-(methylamino)-2-(methylthio)-, ethyl ester
  • -2-(methylsulfanyl)
  • -5-pyrimidinecarboxylate
  • Ethyl 4-(methylamino)
  • 2-(methylthio)-4-(methylamino)-pyrimidine-5-carboxylic acid ethyl ester
  • ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ISO 9001：2015 REACH
  • 5-?Pyrimidinecarboxylic acid, 4-?(methylami)?-?2-?(methylthio)?-?, ethyl ester
  • 76360-82-2
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Amines
  • Aromatics
  • Heterocycles