4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER

Product Name: 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER
CAS No.: 470478-90-1
Chemical Name: 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER
Synonyms: 1-Boc-(4-Bpin)piperazine;Pinacol 4-(1-Boc-4-piperazinyl)phenylboronate;4-(4-tert-Butoxycarbonylpiperazinyl)phenylboronic;4-[4(4,4,5,6-tetramethyl-[1,3,2]dioxaborolan-2-yl);4-(4-Boc-piperazino)phenylboronic Acid Pinacol Este;4-(4-Boc-piperazino)phenylboronic Acid Pinacol Ester;4-(4-BOC-PIPERAZINYL)PHENYLBORONIC ACID PINACOL ESTER;4-(4-N-Boc-piperazinyl)phenylboronic acid pinacol ester;4-[4-(N-Boc)piperazin-1-yl]phenylboronic acid pinacol ester;4-Piperazin-1-ylbenzeneboronic acid pinacol ester, N4-BOC protected
CBNumber: CB2404987
Molecular Formula: C21H33BN2O4
Formula Weight: 388.31
MOL File: 470478-90-1.mol

More

Less

4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER Property

Melting point:: 157 °C
Boiling point:: 501.7±45.0 °C(Predicted)
Density: 1.11
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: 3.06±0.10(Predicted)
color: Off-white to light yellow
InChIKey: ZMAVVXGWEHZLDW-UHFFFAOYSA-N

More

Less

Safety

Risk Statements: 36/37/38
Safety Statements: 26-36
Hazard Note: Harmful
HS Code: 2933998090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BML00082
Product name: 4-(4-tert-Butoxycarbonylpiperazinyl)phenylboronic acid pinacol ester
Purity: Aldrich
Packaging: 1g
Price: $286
Updated: 2025/07/31

TRC

Product number: B710023
Product name: tert-Butyl4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B710023
Product name: tert-Butyl4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-M2470
Product name: 1-Piperazinecarboxylicacid,4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-,1,1-dimethylethylester
Purity: 98.50%
Packaging: 1g
Price: $64
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H60-1-D7
Product name: 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine, N1-Boc protected
Purity: 90%
Packaging: 1g
Price: $152
Updated: 2021/12/16

More

Less

4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER Chemical Properties,Usage,Production

Uses

tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate (cas# 470478-90-1) is a useful reactant for the preparation of 211At- and 125I-?radiolabeled compounds.

Synthesis

73183-34-3

352437-09-3

470478-90-1

Bis(pinacolato)diboron (2.3 g, 9.37 mmol) and potassium acetate (1.7 g, 17.59 mmol) were sequentially added to a stirred solution of 1-Boc-4-(4-bromophenyl)piperazine (2.0 g, 5.86 mmol) in 1,4-dioxane (40 mL) under argon protection. The reaction mixture was purged with argon for 15 min at room temperature. Subsequently, [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (428 mg, 0.58 mmol) was added and the reaction mixture was transferred to a sealed tube and the reaction was stirred for 6 hours at 110 °C. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with water (50 mL) and extracted with ethyl acetate (2 x 50 mL). The organic phases were combined and washed sequentially with water (50 mL) and saturated saline (50 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 4-[4-(N-BOC)piperazin-1-yl]phenylboronic acid pinacol ester (2.0 g, 5.15 mmol, 87% yield) as a white solid. NMR hydrogen spectrum (500 MHz, CDCl3): δ 7.7 (d, J=2.6 Hz, 1H), 6.90 (d, J=8.7 Hz, 2H), 3.6 (m, 4H), 3.2-3.3 (m, 4H).

References

[1] Patent: WO2017/117393, 2017, A1. Location in patent: Page/Page column 205; 206
[2] Patent: US2018/179183, 2018, A1. Location in patent: Paragraph 1274
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 3, p. 453 - 458
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 11, p. 5361 - 5379
[5] Patent: US2012/184520, 2012, A1. Location in patent: Page/Page column 18

4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER Suppliers

Belgium 1 China 150 Germany 2 India 1 United Kingdom 3 United States 12 Global 169

JiNan NBT Fine Chemicals Co., Ltd

Tel: 13075309700
Email: mtzhangwenjian@163.com
Country: China
ProdList: 385
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Carbott PharmTech Inc.

Tel: 0535-6385396
Fax: +86 (535) 638-9971
Email: info@carbottpharm.com
Country: China
ProdList: 957
Advantage: 56

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

More

Less

View Lastest Price from 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER 470478-90-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-09-24

Henan Fengda Chemical Co., Ltd

Product: 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER 470478-90-1
Price: US $34.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Career Henan Chemical Co

Product: 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER 470478-90-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

470478-90-1, 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTERRelated Search:

tert-butyl 4-{2-[4-(trifluoromethoxy)phenyl]acetyl}piperidine -1-carboxylate tert-butyl 4-{3-[(5-bromopyridin-2-yl)oxy]propyl}piperazine1-carboxylate tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 4-[4-(Hydroxymethyl)-1H-1,2,3-triazol-1-yl]-1-piperidinecarboxylic acid tert-butyl ester 2-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER 3-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER 4-Aminophenylboronic acid pinacol ester 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-piperazine 4-(Dimethylamino)phenylboronic acid 1-METHYL-4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]PIPERAZINE [4-(Piperazin-1-yl)phenyl]boronic acid 4-(N-METHYLAMINO)PHENYLBORONIC ACID, PINACOL ESTER (4-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]PHENYL)BORONIC ACID N,N-Diethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 4-(N,N-DIMETHYLAMINO)PHENYLBORONIC ACID, PINACOL ESTER

TERT-BUTYL 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

4-(4-BOC-PIPERAZINYL)PHENYLBORONIC ACID PINACOL ESTER

4-Piperazin-1-ylbenzeneboronic acid pinacol ester, N4-BOC protected 90%

4(N-TERT-BUTOXYCARBONYLPIPERAZINE)BENZENEBORONIC ACID PINACOL ESTER

4-Piperazin-1-ylbenzeneboronic acid pinacol ester, N4-BOC protected

Tert-butyl4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)tetrahydro-1(2H)-pyrazinecarboxylate

4-[4-(N-Boc)piperazin-1-yl]phenylboronic acid pinacol ester

t-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazinecarboxylate

t-butyl4-[4-(4,4,5,5-teramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazinecarboxylate

4(N-tert-Butoxycarbonylpiperazine)benzeneboronic acid pinacol ester 90%

4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER

4-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]PHENYLBORONIC ACID PINACOL ESTER

4-(4-tert-Butoxycarbonylpiperazinyl)phenylboronic

4-(4-Boc-piperazino)phenylboronic Acid Pinacol Ester

tert-butyl 4-(4-(4,4,5,5-tetramethy l-1,3,2-dioxaborolan-2-yl) phenyl)piperazine-1-carboxylate

4-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]piperazine-1-carboxylic acid tert-butyl ester

4-(4-(tert-Butoxycarbonyl)piperazin-1yl)phenylboronic acid picol ester

4-(4-N-Boc-piperazinyl)phenylboronic acid pinacol ester

1-Piperazinecarboxylic acid, 4-[4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-diMethylethyl ester

TERT-BUTYL 3-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL ) PHENYL)-

4-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PHENYL]PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER; TERT-BUTYL 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]PIPERAZINE-1-CARBOXYLATE

4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine, N1-BOC protected 90%

tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate, 4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzeneboronic acid, pinacol ester

tert-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]

4-[4(4,4,5,6-tetramethyl-[1,3,2]dioxaborolan-2-yl)

tert-butyl 4-(4-(hydroxy((3-hydroxy-2,3-dimethylbutan-2-yl)oxy)boryl)phenyl)piperazine-1-carboxylate

tert-butyl 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate

4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-piperazinecarboxylic acid tert-butyl ester

4-(4-Boc-piperazino)phenylboronic Acid Pinacol Este

4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine, N1-BOC protected

Pinacol 4-(1-Boc-4-piperazinyl)phenylboronate

4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate

1-Boc-(4-Bpin)piperazine

4-(4-<i>tert</i>-Butoxycarbonylpiperazinyl)phenylboronic acid pinacol ester

470478-90-1

C21H33BN2O4

Aryl

Boronic ester

Organoborons