ChemicalBook > CAS DataBase List > 3-AMINO-ISONICOTINIC ACID METHYL ESTER

3-AMINO-ISONICOTINIC ACID METHYL ESTER

Product Name: 3-AMINO-ISONICOTINIC ACID METHYL ESTER
CAS No.: 55279-30-6
Chemical Name: 3-AMINO-ISONICOTINIC ACID METHYL ESTER
Synonyms: Tpc-py003;AKOS 93360;METHYL 3-AMINOISONICOTINATE;Methyl 3-Aminoisonicotina...;Methyl3-Aminoisonicotinate>METHYL 3-AMINOPYRIDINE-4-CARBOXYLATE;3-Amino-Isonitinic Acid Methyl Ester;3-AMINO-ISONICOTINIC ACID METHYL ESTER;3-Amino-iosnicotinic acid methyl ester;Methyl3-aminopyridine-4-carboxylate,97%
CBNumber: CB2406062
Molecular Formula: C7H8N2O2
Formula Weight: 152.15
MOL File: 55279-30-6.mol

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3-AMINO-ISONICOTINIC ACID METHYL ESTER Property

Melting point:: 84-86
Boiling point:: 292.5±20.0 °C(Predicted)
Density: 1.238±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 4.05±0.18(Predicted)
color: White to Yellow to Green
InChI: InChI=1S/C7H8N2O2/c1-11-7(10)5-2-3-9-4-6(5)8/h2-4H,8H2,1H3
InChIKey: XLQIGLBALJNHKR-UHFFFAOYSA-N
SMILES: C1=NC=CC(C(OC)=O)=C1N
CAS DataBase Reference: 55279-30-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/38
Safety Statements: 24/25
Hazard Note: Irritant
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ANV00027
Product name: Methyl 3-aminopyridine-4-carboxylate
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 1 g
Price: $185
Updated: 2025/07/31

TCI Chemical

Product number: M2653
Product name: Methyl 3-Aminoisonicotinate
Purity: >98.0%(GC)
Packaging: 1g
Price: $78
Updated: 2025/07/31

TRC

Product number: A604785
Product name: 3-AminoisonicotinicAcidMethylEster
Packaging: 1g
Price: $85
Updated: 2021/12/16

Matrix Scientific

Product number: 045885
Product name: Methyl 3-aminoisonicotinate
Purity: 95+%
Packaging: 1g
Price: $14
Updated: 2021/12/16

Apolloscientific

Product number: OR14139
Product name: Methyl 3-Aminoisonicotinate
Packaging: 5g
Price: $41
Updated: 2021/12/16

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3-AMINO-ISONICOTINIC ACID METHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Yellow powder

Uses

3-Aminoisonicotinic Acid Methyl Ester is a useful synthetic intermediate. It is used in the synthesis of morpholinophenylquinazolines and related derivatives as PI3 kinase p110α inhibitors. It is also used to synthesize aryl tetrahydropyridine inhibitors of farnesyltransferase as antitumor agents.

Synthesis

67-56-1

7579-20-6

55279-30-6

3-Aminoisonicotinic acid (3.55 g, 25.7 mmol) was added with concentrated sulfuric acid (2.5 ml) and methanol (50 ml), and the reaction was heated to reflux at 80°C for 3 days. After completion of the reaction, methanol was removed by evaporation and the residue was diluted with deionized water (75 ml) and heated to 80 °C. Solid sodium carbonate was added slowly until no gas was produced. The reaction mixture was cooled to room temperature and extracted with dichloromethane (2 x 100 ml). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give methyl 3-aminoisonicotinate as a beige solid (2.36 g, 60% yield). The product was characterized by 1H NMR (500 MHz, DMSO-d6): δ 8.24 (1H, s), 7.74 (1H, d, J=5.3 Hz), 7.46 (1H, d, J=5.2 Hz), 6.67 (2H, brs), 3.83 (3H, s). The mass spectrum (ES+) showed the molecular ion peak m/z 153 ([M+H]+).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 7, p. 1359 - 1362
[2] Patent: WO2005/49613, 2005, A1. Location in patent: Page/Page column 38
[3] Patent: WO2008/74749, 2008, A1. Location in patent: Page/Page column 62-63
[4] Chemical Communications, 2016, vol. 52, # 59, p. 9283 - 9286

3-AMINO-ISONICOTINIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Acetic anhydride Acetamide 3,4-Pyridinedicarboxylic acid Ethyl acetate Sodium bicarbonate Bromine Dichloromethane Acetic acid Methanol Sodium hydroxide Thionyl chloride

Preparation Products

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View Lastest Price from 3-AMINO-ISONICOTINIC ACID METHYL ESTER manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3-AMINO-ISONICOTINIC ACID METHYL ESTER 55279-30-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Career Henan Chemical Co

Product: 3-AMINO-ISONICOTINIC ACID METHYL ESTER 55279-30-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500KG
Release date: 2018-12-20

55279-30-6, 3-AMINO-ISONICOTINIC ACID METHYL ESTERRelated Search:

3-AMINO-ISONICOTINIC ACID ETHYL ESTER 3-Aminoisonicotinic acid hydrate (1:1) 3-Aminoisonicotinic acid Methyl isonicotinate Ethyl 6-aminonicotinate Ethyl 2-Aminoisonicotinate 3-AMINO-ISONICOTINIC ACID METHYL ESTER 3-AMINO-2-CHLORO-ISONICOTINIC ACID METHYL ESTER 3-Amino-2,6-dichloro-isonicotinic acid ethyl ester ethyl 3-amino-5-cyano-2-methylpyridine-4-carboxylate ETHYL 2-CHLORO-3-CYANO-6-METHYL-5-NITROPYRIDINE-4-CARBOXYLATE 3-Amino-2-methoxy-6-methyl-4-pyridinecarboxylicacidethylester 3-AMINO-ISONICOTINIC ACID ETHYL ESTER HCL methyl 5-(tert-butoxycarbonylamino)-2-fluoroisonicotinate Ethyl 5-aminopyridine-3-carboxylate ,97% 3-AMINO-ISONICOTINIC ACID ETHYL ESTER DIHYDROCHLORIDE AKOS 93357 RARECHEM AL BW 1166

METHYL 3-AMINOPYRIDINE-4-CARBOXYLATE

METHYL 3-AMINOISONICOTINATE

AKOS 93360

3-AMINO-ISONICOTINIC ACID METHYL ESTER

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3-AMINOPYRIDINE-4-CARBOXYLIC ACID METHYL ESTER

3-Amino-isonicotinic acid methyl ester ,98%

Tpc-py003

2-Amino-1,7-naphthyridine-3-carbonitrile

Methyl 3-Aminoisonicotina...

3-Amino-Isonitinic Acid Methyl Ester

Methyl ester of 3-aMinopyridine-4-carboxylic acid

Methyl 3-aminopyridine-4-carboxylate, 3-Amino-4-(methoxycarbonyl)pyridine

3-Amino-iosnicotinic acid methyl ester

Methyl3-Aminoisonicotinate&gt

4-Pyridinecarboxylic acid, 3-amino-, methyl ester

Methyl3-aminopyridine-4-carboxylate,97%

3-AMINO-ISONICOTINIC ACID METHYL ESTER ISO 9001：2015 REACH

3-Aminopyridine-4-carboxylic acid methyl este

55279-30-6

Pyridine

pharmacetical

Esters

Pyridines