ChemicalBook > CAS DataBase List > R-(+)-ETOMOXIR
R-(+)-ETOMOXIR
Description Application- Product Name
- R-(+)-ETOMOXIR
- CAS No.
- 124083-20-1
- Chemical Name
- R-(+)-ETOMOXIR
- Synonyms
- B80754;CS-1432;B807-54;B 80754;B-80754;B 807-54;B-807-54;S-(+)-ETOMOXIR;R-(+)-ETOMOXIR;R(+)-Etomoxir free acid
- CBNumber
- CB2407236
- Molecular Formula
- C17H23ClO4
- Formula Weight
- 326.82
- MOL File
- 124083-20-1.mol
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R-(+)-ETOMOXIR Property
- Melting point:
- 32-34°C
- Boiling point:
- 405.0±25.0 °C(Predicted)
- Density
- 1.163
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- ≥32.7 mg/mL in DMSO; ≥109.6 mg/mL in EtOH; ≥48.3 mg/mL in H2O with gentle warming
- form
- Powder
- InChI
- InChI=1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3/t17-/m1/s1
- InChIKey
- DZLOHEOHWICNIL-QGZVFWFLSA-N
- SMILES
- O1C[C@]1(CCCCCCOC1=CC=C(Cl)C=C1)C(OCC)=O
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- E933505
- Product name
- R-(+)-Etomoxir
- Packaging
- 50mg
- Price
- $1620
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 10182
- Product name
- S-(+)-Etomoxir
- Packaging
- 25mg
- Price
- $2000
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A3404
- Product name
- Etomoxir
- Packaging
- 10mg
- Price
- $120
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0002658
- Product name
- Etomoxir
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $303.45
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A3404
- Product name
- Etomoxir
- Packaging
- 50mg
- Price
- $510
- Updated
- 2021/12/16
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R-(+)-ETOMOXIR Chemical Properties,Usage,Production
Description
Etomoxir, or 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane.This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPARα. An off-target effect has been demonstrated at high concentrations of etomoxir on Coenzyme-A (CoA) metabolism.
Application
Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
Chemical Properties
Colourless Oil
Uses
An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of long-chain acyl CoA esters. A strong inhibitor of mitochondrial CPT1 and is a candidate as an anti-diabetic drug
Definition
ChEBI: (2R)-2-[6-(4-chlorophenoxy)hexyl]-2-oxiranecarboxylic acid ethyl ester is an aromatic ether.
Biological Activity
etomoxir is a cell-permeable, irreversible, and stereospecific compound. etomoxir is shown to inhibit carnitine palmitoyltransferase (cpt)-1 and dgat activity in the mitochondria of rat heart h9c2 myoblastic cells at a concentration of 1-80 μm and 40 μm, respectively.
R-(+)-ETOMOXIR Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from R-(+)-ETOMOXIR manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Etomoxir 124083-20-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Etomoxir 124083-20-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
Career Henan Chemical Co
- Product
- Etomoxir 124083-20-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10