(-)-MK-801 MALEATE
- Product Name
- (-)-MK-801 MALEATE
- CAS No.
- 77086-22-7
- Chemical Name
- (-)-MK-801 MALEATE
- Synonyms
- mk801;(+)MK801;(+)MK108;MK 801 ;MK801;(-)-MK-801 MALEATE;Dizocipine maleate;(+)Mk801/MK801/MK-801;(+)-MK-801·Maleic acid;MK-801(Dizocilpine)Maleate;(+/-)-mk-801 hydrogen maleate
- CBNumber
- CB2407483
- Molecular Formula
- C20H19NO4
- Formula Weight
- 337.38
- MOL File
- 77086-22-7.mol
(-)-MK-801 MALEATE Property
- Melting point:
- 208.5-210°
- alpha
- D20 +114° (c = 0.0128 g/2 ml ethanol)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO: >20 mg/mL
- form
- solid
- color
- white
- optical activity
- [α]25/D +117°, c = 1 in methanol(lit.)
- InChIKey
- QLTXKCWMEZIHBJ-FWHYOZOBSA-N
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- HP1093575
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
H361Suspected of damaging fertility or the unborn child
H370Causes damage to organs
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P307+P311IF exposed: call a POISON CENTER or doctor/physician.
P308+P313IF exposed or concerned: Get medical advice/attention.
P314Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M107
- Product name
- (+)-MK-801 hydrogen maleate
- Purity
- powder
- Packaging
- 5mg
- Price
- $119
- Updated
- 2024/03/01
- Product number
- 475878
- Product name
- (+)-MK 801 Maleate
- Packaging
- 10mg
- Price
- $152
- Updated
- 2022/05/15
- Product number
- J63917
- Product name
- Dizocilpine maleate, 99+%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- J63917
- Product name
- Dizocilpine maleate, 99+%
- Packaging
- 50mg
- Price
- $369
- Updated
- 2024/03/01
- Product number
- 10009019
- Product name
- (+)-MK-801 (hydrogen maleate)
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $72
- Updated
- 2024/03/01
(-)-MK-801 MALEATE Chemical Properties,Usage,Production
Uses
Dizocilpine maleate is used to interact at the NMDA-associated ion channel, preventing Ca2+ flux and blocking NMDA-induced depolarizations. (+)-MK 801 demonstrates potent neuroprotective effects against excitotoxic insult, showing substantial protection against neuron loss produced by NMDA and quinolinic acid introduction.
Uses
(-)-MK-801 MALEATE is probe for NMDA receptors
Uses
(-)-MK-801 MALEATE acts as an NMDA receptor antagonist. It is selective and potent, but noncompetitive, used in various ischemia treatments.
Definition
ChEBI: Dizocilpine maleate is a maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid. It has a role as an anaesthetic, an anticonvulsant, a neuroprotective agent, a nicotinic antagonist and a NMDA receptor antagonist. It is a maleate salt and a tetracyclic antidepressant. It contains a dizocilpine(1+).
General Description
A highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, preventing Ca2+ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca2+ entry induced seizures.
Biological Activity
(-)-MK-801 MALEATE is a potent, selective and non-competitive NMDA receptor antagonist. Acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca 2+ flux. An effective anti-ischemic agent in several animal models. Also available as part of the Mixed NMDA Receptor Tocriset™ .
Biochem/physiol Actions
Primary TargetNMDA receptor
storage
Room temperature
References
[1] wong eh, kemp ja, priestley t, knight ar, woodruff gn, iversen ll . the anticonvulsant mk-801 is a potent n-methyl-d-aspartate antagonist. proc natl acad sci u s a. 1986 sep;83(18):7104-8.
(-)-MK-801 MALEATE Preparation Products And Raw materials
Raw materials
Preparation Products
(-)-MK-801 MALEATE Suppliers
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View Lastest Price from (-)-MK-801 MALEATE manufacturers
- Product
- (-)-MK-801 MALEATE 77086-22-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%HPLC
- Supply Ability
- 100KG
- Release date
- 2020-02-05