MSOP
- Product Name
- MSOP
- CAS No.
- 66515-29-5
- Chemical Name
- MSOP
- Synonyms
- MSOP;2-Methyl-O- phosphonoserine;Serine, 2-methyl-O-phosphono-;(RS)-α-Methylserine-O-phosphate;(R,S)-a-Methylserine-O-phosphate;(RS)-ALPHA-METHYLSERINE-O-PHOSPHATE;MSOP, group III metabotropic glutamate receptor antagonist
- CBNumber
- CB2407711
- Molecular Formula
- C4H10NO6P
- Formula Weight
- 199.1
- MOL File
- 66515-29-5.mol
MSOP Property
- Boiling point:
- 454.0±55.0 °C(Predicted)
- Density
- 1.681±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- H2O: soluble3mg/mL, clear (warmed)
- form
- powder
- pka
- 1.66±0.10(Predicted)
- color
- white to beige
- Water Solubility
- Soluble to 100 mM in water
N-Bromosuccinimide Price
- Product number
- 0803
- Product name
- MSOP
- Packaging
- 25
- Price
- $432
- Updated
- 2021/12/16
- Product number
- 0803
- Product name
- MSOP
- Packaging
- 5
- Price
- $115
- Updated
- 2021/12/16
- Product number
- M755425
- Product name
- MSOP
- Packaging
- 100mg
- Price
- $800
- Updated
- 2021/12/16
- Product number
- 456675
- Product name
- MSOP
- Packaging
- 10mg
- Price
- $439
- Updated
- 2021/12/16
- Product number
- M755425
- Product name
- MSOP
- Packaging
- 50mg
- Price
- $450
- Updated
- 2021/12/16
MSOP Chemical Properties,Usage,Production
Uses
MSOP is a selective antagonist of group III mGlu receptors.
Biological Activity
MSOP is a selective group III metabotropic glutamate receptor antagonist. Displays an apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons.
in vivo
It is found that TBOA-induced antinociceptive effects are significantly blocked by intrathecal co-administration of MSOP (second phase of formalin model: F3,16=30.96, P<0.001; CFA model: F3,16=30.77, P<0.001). As expected, intrathecal TBOA (10 μg) reduces the number of formalin-induced flinches and shakes by 47% of the value in the saline-treated group in the second phase (P<0.001) and blocked the CFA-induced decrease in ipsilateral paw withdrawal latency by 60% of the value in the saline-treated group (P=0.01). The number of formalin-induced flinches in the second phase in the group treated with MSOP and TBOA is increased by 56% (P=0.04) of the value in the TBOA-treated group. CFA-induced paw withdrawal latency in the group treated with MSOP and TBOA is decreased by 86% (P=0.03) of the value in the TBOA-treated group[2].
storage
Store at RT
MSOP Preparation Products And Raw materials
Raw materials
Preparation Products
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