4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID

Product Name: 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
CAS No.: 33763-20-1
Chemical Name: 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
Synonyms: AKOS BBS-00004452;IFLAB-BB F1912-0027;5-Carboxy-2-phenylthiazole;4-methyl-2-phenyl-5-thiazolecarboxylate;4-Methyl-2-phenyl-5-thiazolecarboxylicacid;2-Phenyl-4-methyl-5-thiazolecarboxylic acid;4-METHYL-2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID;5-Thiazolecarboxylic acid, 4-methyl-2-phenyl-;4-Methyl-2-phenylthiazole-5-carboxylicacid,97%;4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
CBNumber: CB2409407
Molecular Formula: C11H9NO2S
Formula Weight: 219.26
MOL File: 33763-20-1.mol

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4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Property

Melting point:: 210-212°C
Boiling point:: 424.0±37.0 °C(Predicted)
Density: 1.319±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 1.20±0.37(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 33763-20-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-26-36/37/39
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B399915
Product name: 4-Methyl-2-phenyl-1,3-thiazole-5-carboxylicAcid
Packaging: 250mg
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 043211
Product name: 4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic acid
Purity: >95%
Packaging: 5g
Price: $70
Updated: 2021/12/16

Matrix Scientific

Product number: 043211
Product name: 4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic acid
Purity: >95%
Packaging: 500mg
Price: $13
Updated: 2021/12/16

Matrix Scientific

Product number: 043211
Product name: 4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic acid
Purity: >95%
Packaging: 1g
Price: $19
Updated: 2021/12/16

AK Scientific

Product number: Z2892
Product name: 4-Methyl-2-(phenyl)-1,3-thiazol-5-carboxylicacid
Packaging: 1g
Price: $41
Updated: 2021/12/16

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4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic Acid is a useful reagent in Pd-catalyzed decarboxylative C-H cross-coupling of oxazoles and thiazoles.

Synthesis

53715-64-3

33763-20-1

General method: 2N aqueous sodium hydroxide solution was slowly added to a methanol solution containing ethyl 4-methyl-2-phenyl-1,3-thiazole-5-carboxylate (1 eq.) at room temperature. The reaction mixture was stirred continuously for 4 hours at room temperature. After completion of the reaction, the methanol solvent was removed by rotary evaporator. Subsequently, the pH of the reaction mixture was adjusted to 5-6 with 1N hydrochloric acid solution.The precipitated white solid was collected by filtration and processed by drying to finally give 4-methyl-2-phenylthiazole-5-carboxylic acid (1a-i).

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 4, p. 685 - 695
[2] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 96 - 107
[3] Justus Liebigs Annalen der Chemie, 1974, p. 1195 - 1205
[4] Heterocycles, 2014, vol. 89, # 2, p. 453 - 464
[5] Molecules, 2014, vol. 19, # 7, p. 9240 - 9256

4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

THIOBENZAMIDE Sodium hydroxide Ethyl 2-chloroacetoacetate

Preparation Products

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4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Suppliers

Belgium 1 Canada 1 China 64 France 1 Germany 4 India 3 United Kingdom 8 United States 14 Global 96

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View Lastest Price from 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID 33763-20-1
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-21

33763-20-1, 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACIDRelated Search:

Ethyl 4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate 4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]THIAZOLE-5-CARBOXYLIC ACID ETHYL 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLATE Febuxostat 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID 2-PHENYLTHIAZOLE ETHYL 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID 4-METHYL-2-(4-METHYLPHENYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID ETHYL 4-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBOXYLATE METHYL 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE 2-(3,4-DIMETHOXY-PHENYL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID 4-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBOXYLIC ACID 2-METHYL-5-PHENYL-1,3-THIAZOLE-4-CARBOXYLIC ACID 2-(3,4-DIMETHOXY-PHENYL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER ETHYL 2-(2-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE 2-PHENYL-1,3-THIAZOLE-4,5-DICARBOXYLIC ACID 2-PHENYL-1,3-THIAZOLE-4,5-DICARBOXYLIC ACID DIETHYL ESTER

4-METHYL-2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID

4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID

AKOS BBS-00004452

IFLAB-BB F1912-0027

4-Methyl-2-phenyl-5-thiazolecarboxylicacid

4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic acid, Tech.

5-Carboxy-2-phenylthiazole

2-Phenyl-4-methyl-5-thiazolecarboxylic acid

4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic acid ,97%

4-methyl-2-phenyl-5-thiazolecarboxylate

5-Thiazolecarboxylic acid, 4-methyl-2-phenyl-

4-Methyl-2-phenylthiazole-5-carboxylicacid,97%

33763-20-1

33673-20-1