1,4-DICHLOROISOQUINOLINE
- Product Name
- 1,4-DICHLOROISOQUINOLINE
- CAS No.
- 15298-58-5
- Chemical Name
- 1,4-DICHLOROISOQUINOLINE
- Synonyms
- 1,4-DICHLOROISOQUINOLINE;Isoquinoline, 1,4-dichloro-;1,4-DICHLOROISOQUINOLINE ISO 9001：2015 REACH
- CBNumber
- CB2421674
- Molecular Formula
- C9H5Cl2N
- Formula Weight
- 198.05
- MOL File
- 15298-58-5.mol
1,4-DICHLOROISOQUINOLINE Property
- Melting point:
- 92-94℃
- Boiling point:
- 310.9±22.0 °C(Predicted)
- Density
- 1.407
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.02±0.31(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D435408
- Product name
- 1,4-Dichloroisoquinoline
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D435408
- Product name
- 1,4-Dichloroisoquinoline
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR914185
- Product name
- 1,4-Dichloroisoquinoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $153
- Updated
- 2021/12/16
- Product number
- 3H32-5-PF
- Product name
- 1,4-Dichloroisoquinoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $168
- Updated
- 2021/12/16
- Product number
- 074046
- Product name
- 1,4-Dichloroisoquinoline
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $297
- Updated
- 2021/12/16
1,4-DICHLOROISOQUINOLINE Chemical Properties,Usage,Production
Synthesis
56241-09-9
15298-58-5
The general procedure for the synthesis of 1,4-dichloroisoquinoline from 4-chloro-1(2H)-isoquinolinone was as follows: 4-chloro-2H-isoquinolin-1-one (3.1 g, 17 mmol) was dissolved in phosphorus trichloride (POCl3, 20 mL), and the reaction was carried out at reflux for 4 hours. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure. The residue was extracted with chloroform (CHCl3, 50 mL) and neutralized with 1N sodium hydroxide (NaOH) solution. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography (Biotage Flash 40M) with hexane solution of 5% ethyl acetate (EtOAc) as eluent, resulting in the target product 1,4-dichloroisoquinoline (2.3 g, 66% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and mass spectrometry (MS): 1H NMR δ ppm 7.77 (ddd, J = 8.31, 7.09, 1.22 Hz, 1H), 7.88 (ddd, J = 8.31, 7.09, 1.22 Hz, 1H), 8.23 (d, J = 8.31 Hz, 1H), and 8.34 (s, 1H), 8.36 (d, J = 8.56 Hz, 1H); MS m/z 198 ([M + H]+).
References
[1] Patent: WO2005/51410, 2005, A1. Location in patent: Page/Page column 93
1,4-DICHLOROISOQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,4-DICHLOROISOQUINOLINE manufacturers
- Product
- 1,4-Dichloroisoquinoline 15298-58-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.3%
- Supply Ability
- 100 tons
- Release date
- 2022-02-08