OM99-2

Product Name: OM99-2
CAS No.: 314266-76-7
Chemical Name: OM99-2
Synonyms: OM99-2;EVNL-PSI-AAEF;InSolution? OM99-2;InSolution OM99-2 - CAS 314266-76-7 - Calbiochem;GLU-VAL-ASN-(2R,4S,5S)-5-AMINO-*4-HYDROXY-2,7-DIMET;glu-val-asn-[(2r,4s,5s)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-ala-glu-phe;[2-AMINOBENZOYL-GLY1]-GALANIN FRAGMENT (1-10)-LYS(RETRO-M-NITRO-TYR) AMIDE HUMAN;H-GLU-VAL-ASN-[(2R,4S,5S)-5-AMINO-4-HYDROXY-2,7-DIMETHYL-OCTANOYL]-ALA-GLU-PHE-OH;Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-Ala-Glu-Phe >93% (HPLC), solid;[2-aminobenzoyl-gly1]-galanin fragment (1-10)-lys(retro-m-nitro-tyr) amide, human trifluoroacetate salt
CBNumber: CB2421700
Molecular Formula: C41H64N8O14
Formula Weight: 892.99
MOL File: 314266-76-7.mol

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OM99-2 Property

Boiling point:: 1346.5±65.0 °C(Predicted)
Density: 1.289±0.06 g/cm3(Predicted)
storage temp.: −20°C
form: solid
pka: 3.48±0.10(Predicted)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 496000
Product name: InSolution OM99-2 - CAS 314266-76-7 - Calbiochem
Purity: An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2.
Packaging: 250μg
Price: $617
Updated: 2025/07/31

Sigma-Aldrich

Product number: G8291
Product name: Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-Ala-Glu-Phe
Purity: >93% (HPLC), solid
Packaging: 0.5mg
Price: $959
Updated: 2022/05/15

American Custom Chemicals Corporation

Product number: CCH0002987
Product name: GLU-VAL-ASN-[(2R,4S,5S)-5-AMINO-4-HYDROXY-2,7-DIMETHYLOCTANOYL]-ALA-GLU-PHE
Purity: 95.00%
Packaging: 0.5MG
Price: $1232.39
Updated: 2021/12/16

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OM99-2 Chemical Properties,Usage,Production

Uses

OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 is significantly advanced the development of BACE1 inhibitor[2]. OM99-2 has the potential for the research of the Alzheimer's disease[3].

Biological Activity

Cell permeable: no', 'Primary Target
human brain memapsin 2', 'Product does not compete with ATP.', 'Reversible: no', 'Target Ki: 1.6 nM against recombinant memapsin 2; 9.58 nM against recombinant pro-memapsin 2; 48 nM against cathepsin D

IC 50

BACE1

References

[1] Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523. DOI:10.1021/ja000300g
[2] Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4. DOI:10.3389/fnmol.2020.00137
[3] Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119. DOI:10.1080/713609213
[4] Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422. DOI:10.1021/ja0304493

OM99-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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OM99-2 Suppliers

China 33 Switzerland 1 United States 5 Global 39

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314266-76-7, OM99-2Related Search:

OM99-2 TRIFLUOROACETATE SALT [2-AMINOBENZOYL-GLY1]-GALANIN FRAGMENT (1-10)-LYS(RETRO-M-NITRO-TYR) AMIDE, HUMAN TRIFLUOROACETATE SALT OM99-2

OM99-2

H-GLU-VAL-ASN-[(2R,4S,5S)-5-AMINO-4-HYDROXY-2,7-DIMETHYL-OCTANOYL]-ALA-GLU-PHE-OH

EVNL-PSI-AAEF

GLU-VAL-ASN-(2R,4S,5S)-5-AMINO-*4-HYDROXY-2,7-DIMET

[2-AMINOBENZOYL-GLY1]-GALANIN FRAGMENT (1-10)-LYS(RETRO-M-NITRO-TYR) AMIDE HUMAN

[2-aminobenzoyl-gly1]-galanin fragment (1-10)-lys(retro-m-nitro-tyr) amide, human trifluoroacetate salt

glu-val-asn-[(2r,4s,5s)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-ala-glu-phe

OM99-2;[2-AMINOBENZOYL-GLY1]-GALANIN FRAGMENT (1-10)-LYS(RETRO-M-NITRO-TYR) AMIDE, HUMAN TRIFLUOROACETATE SALT

InSolution? OM99-2

InSolution OM99-2 - CAS 314266-76-7 - Calbiochem

L-Phenylalanine, L-α-glutamyl-L-valyl-L-asparaginyl-(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl-L-alanyl-L-α-glutamyl-

Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-Ala-Glu-Phe >93% (HPLC), solid

314266-76-7

C72H98N18O20

C41H64N8O14

R to Z

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme

Enzyme Inhibitors

Biochemicals and Reagents

BioChemical

beta-Secretase

Galanin Degrading Zinc-MetallopeptidaseEnzyme Substrates

Galanin degrading zinc-metallopeptidasePeptides for Cell Biology

Enzyme Substrates

Galanins

Neuropeptides

Protease Substrates

Substrates by Enzyme