ALAMETHICIN

Product Name: ALAMETHICIN
CAS No.: 59588-86-2
Chemical Name: ALAMETHICIN
Synonyms: f-50;U-22324;ALMETHICIN;ALAMETHICIN;ALAMETHACIN;alamethicini;alamethicinf30;alamethicingamma;ANTIBIOTIC U-22324
CBNumber: CB2423618
Molecular Formula: C92H150N22O25
Formula Weight: 1964.31
MOL File: 59588-86-2.mol

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ALAMETHICIN Property

Melting point:: 267-270℃
RTECS: AY1900000
storage temp.: 2-8°C
solubility: Soluble in DMSO and ethanol.
form: Powder

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 3462 6.1/PG 3
WGK Germany: 3
F: 10-21
HazardClass: 6.1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J63829
Product name: Alamethicin
Packaging: 1mg
Price: $160
Updated: 2024/03/01

Alfa Aesar

Product number: J63829
Product name: Alamethicin
Packaging: 5mg
Price: $553.65
Updated: 2024/03/01

Usbiological

Product number: 001726
Product name: Alamethicin
Packaging: 1mg
Price: $262
Updated: 2021/12/16

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ALAMETHICIN Chemical Properties,Usage,Production

Uses

Alamethicin is used as a channel-forming ionophore that activates membrane enzymes, membrane channel-forming peptide. It is a 20-amino acid channel-forming peptide antibiotic that can function as a monovalent cation ionophore. Alamethicin has been used to develop methods for the routine assessment of potential new drug candidates to elicit their pharmacokinetic drug interactions.

Enzyme inhibitor

These voltage-dependent, channel-forming, peptaibol antibiotics (MWAlamethicin F-30 = 1964.40; CAS 27061-78-5) from the soil fungus Trichoderma viride NRRL 3199 are membrane-active oligopeptides isolated from that exhibit anti-bacterial and anti-fungal properties. Peptaibols are amphipathic, usually highly helical in structure, and typically form voltage dependent ion channels that uncouple oxidative phosphorylation, often attended by in bacterial and fungal cell death. Alamethicin F-30 has the sequence Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib- Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phe-OH; Alamethicin F- 50 has the sequence Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly- Leu-Aib-Pro-Val-Aib Aib-Gln-Gln-Phe-OH; and Alamethicin II has the sequence Ac-Aib-Pro-Aib-Ala-Aib-Aib-Gln-Aib-Val-Aib-Gly-Leu-Aib- Pro-Val-Aib-Aib-Glu-Gln-Phe-OH. Note: The name “peptaibol” is derived from the prefix “pep-“, the central syllable “aib”, and the suffix “-ol” to designate its peptide structure, the presence of an a-aminoisobutyryl unit, and the C-terminal alcohol.

ALAMETHICIN Preparation Products And Raw materials

Raw materials

Preparation Products

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ALAMETHICIN Suppliers

China 30 Germany 3 Switzerland 2 United Kingdom 1 United States 7 Global 43

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59588-86-2, ALAMETHICINRelated Search:

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alamethicinf30

alamethicingamma

alamethicini

f-50

U-22324

ANTIBIOTIC U-22324

ALMETHICIN

ALAMETHACIN

ALAMETHICIN

59588-86-2

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