ALAMETHICIN
- Product Name
- ALAMETHICIN
- CAS No.
- 59588-86-2
- Chemical Name
- ALAMETHICIN
- Synonyms
- f-50;U-22324;ALMETHICIN;ALAMETHICIN;ALAMETHACIN;alamethicini;alamethicinf30;alamethicingamma;ANTIBIOTIC U-22324
- CBNumber
- CB2423618
- Molecular Formula
- C92H150N22O25
- Formula Weight
- 1964.31
- MOL File
- 59588-86-2.mol
ALAMETHICIN Property
- Melting point:
- 267-270℃
- RTECS
- AY1900000
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO and ethanol.
- form
- Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P321Specific treatment (see … on this label).
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- J63829
- Product name
- Alamethicin
- Packaging
- 1mg
- Price
- $160
- Updated
- 2024/03/01
- Product number
- J63829
- Product name
- Alamethicin
- Packaging
- 5mg
- Price
- $553.65
- Updated
- 2024/03/01
- Product number
- 001726
- Product name
- Alamethicin
- Packaging
- 1mg
- Price
- $262
- Updated
- 2021/12/16
ALAMETHICIN Chemical Properties,Usage,Production
Uses
Alamethicin is used as a channel-forming ionophore that activates membrane enzymes, membrane channel-forming peptide. It is a 20-amino acid channel-forming peptide antibiotic that can function as a monovalent cation ionophore. Alamethicin has been used to develop methods for the routine assessment of potential new drug candidates to elicit their pharmacokinetic drug interactions.
Enzyme inhibitor
These voltage-dependent, channel-forming, peptaibol antibiotics (MWAlamethicin F-30 = 1964.40; CAS 27061-78-5) from the soil fungus Trichoderma viride NRRL 3199 are membrane-active oligopeptides isolated from that exhibit anti-bacterial and anti-fungal properties. Peptaibols are amphipathic, usually highly helical in structure, and typically form voltage dependent ion channels that uncouple oxidative phosphorylation, often attended by in bacterial and fungal cell death. Alamethicin F-30 has the sequence Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib- Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phe-OH; Alamethicin F- 50 has the sequence Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly- Leu-Aib-Pro-Val-Aib Aib-Gln-Gln-Phe-OH; and Alamethicin II has the sequence Ac-Aib-Pro-Aib-Ala-Aib-Aib-Gln-Aib-Val-Aib-Gly-Leu-Aib- Pro-Val-Aib-Aib-Glu-Gln-Phe-OH. Note: The name “peptaibol” is derived from the prefix “pep-“, the central syllable “aib”, and the suffix “-ol” to designate its peptide structure, the presence of an a-aminoisobutyryl unit, and the C-terminal alcohol.
ALAMETHICIN Preparation Products And Raw materials
Raw materials
Preparation Products
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