3-METHYLENECYCLOBUTANECARBOXYLIC ACID
Uses- Product Name
- 3-METHYLENECYCLOBUTANECARBOXYLIC ACID
- CAS No.
- 15760-36-8
- Chemical Name
- 3-METHYLENECYCLOBUTANECARBOXYLIC ACID
- Synonyms
- 3-methylenecyclobutane-1-carboxylic acid;3-Methylidenecyclobutane-1-carboxylic acid;RARECHEM AL BO 0919;3-Methylenecyclobutanecarboxylic;3-methylene-cyclobutanecarboxylicaci;3-METHYLENECYCLOBUTANECARBOXYLIC ACID;3-methylidenecyclobutanecarboxylic acid;Cyclobutanecarboxylic acid, 3-Methylene-;3-Methylenecyclobutane-1-carboxylicacid97%;3-Methylenecyclobutane-1-carboxylic acid 97%
- CBNumber
- CB2427333
- Molecular Formula
- C6H8O2
- Formula Weight
- 112.13
- MOL File
- 15760-36-8.mol
3-METHYLENECYCLOBUTANECARBOXYLIC ACID Property
- Boiling point:
- 102.5-103 °C(Press: 11 Torr)
- Density
- 1.12±0.1 g/cm3(Predicted)
- refractive index
- 1.46
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 4.52±0.20(Predicted)
- form
- liquid
- color
- Clear, colourless
- InChI
- InChI=1S/C6H8O2/c1-4-2-5(3-4)6(7)8/h5H,1-3H2,(H,7,8)
- InChIKey
- NNKLICLIBKMDOY-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)CC(=C)C1
N-Bromosuccinimide Price
- Product number
- M218798
- Product name
- 3-MethylenecyclobutanecarboxylicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M218798
- Product name
- 3-MethylenecyclobutanecarboxylicAcid
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- M218798
- Product name
- 3-MethylenecyclobutanecarboxylicAcid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 059133
- Product name
- 3-Methylenecyclobutanecarboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $247
- Updated
- 2021/12/16
- Product number
- Y3237
- Product name
- 3-Methylenecyclobutanecarboxylicacid
- Packaging
- 5g
- Price
- $264
- Updated
- 2021/12/16
3-METHYLENECYCLOBUTANECARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
Because it contains a cyclobutane skeleton, 3-methylenecyclobutane carboxylic acid can be used as a synthetic intermediate for functional organic molecules containing a cyclobutane skeleton. By utilizing the chemical transformation properties of this substance, different functional groups can be introduced onto the cyclobutane skeleton, thereby achieving the regulation of the properties of the target organic molecule.
Synthesis
15760-35-7
15760-36-8
Step 1: Preparation of 3-methylenecyclobutanecarboxylic acid Potassium hydroxide (264 g, 4.7 mol) was added to a mixed solution of 3-methylenecyclobutanecarbonitrile (110 g, 1.18 mol) in ethanol (500 mL) and water (500 mL), and the resulting mixture was heated to reflux overnight. Upon completion of the reaction, ethanol was removed by distillation under reduced pressure. The remaining solution was cooled to below 10 °C and acidified with concentrated hydrochloric acid to pH 1. The mixture was extracted with ethyl acetate (2 × 500 mL), the organic phases were combined and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give the title compound 3-methylenecyclobutanecarboxylic acid (132 g, 100% yield) as a yellow oil.
References
[1] Patent: US2013/79324, 2013, A1. Location in patent: Paragraph 0934; 0935
[2] Patent: US2014/142081, 2014, A1. Location in patent: Paragraph 0242; 0244
[3] Patent: WO2014/79136, 2014, A1. Location in patent: Page/Page column 89-90
[4] Patent: WO2018/89355, 2018, A1. Location in patent: Page/Page column 221; 222
[5] Patent: WO2015/129926, 2015, A1. Location in patent: Page/Page column 108
3-METHYLENECYCLOBUTANECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
3-METHYLENECYCLOBUTANECARBOXYLIC ACID Suppliers
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- Country
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View Lastest Price from 3-METHYLENECYCLOBUTANECARBOXYLIC ACID manufacturers
- Product
- 3-Methylenecyclobutanecarboxylic acid 15760-36-8
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-08-05
- Product
- 3-METHYLENECYCLOBUTANECARBOXYLIC ACID 15760-36-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24