ChemicalBook > CAS DataBase List > Erythromycin stearate

Erythromycin stearate

Product Name
Erythromycin stearate
CAS No.
643-22-1
Chemical Name
Erythromycin stearate
Synonyms
erypar;pfizer-e;gallimycin;bristamycin;oe7;Wemid;Ethryn;ethril;Eryprim;eratrex
CBNumber
CB2436793
Molecular Formula
C55H103NO15
Formula Weight
1018.42
MOL File
643-22-1.mol
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Erythromycin stearate Property

Melting point:
77-79°C
storage temp. 
2-8°C
solubility 
ethanol: soluble50mg/mL, clear to very slightly hazy, colorless
color 
white to off-white
Stability:
Stable. Combustible. Incompatible with acids, strong oxidizing agents.
EPA Substance Registry System
Erythromycin stearate (643-22-1)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
42/43-36/37/38
Safety Statements 
36-26
WGK Germany 
2
RTECS 
KF5785000
HS Code 
29415000
Hazardous Substances Data
643-22-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E1500800
Product name
Erythromycin stearate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
e1500800
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
BP488
Product name
Erythromycin stearate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$267
Updated
2024/03/01
Sigma-Aldrich
Product number
1248006
Product name
Erythromycin stearate
Packaging
200mg
Price
$198
Updated
2024/03/01
Usbiological
Product number
E3454-05
Product name
Erythromycin Stearate
Packaging
10g
Price
$297
Updated
2021/12/16
Usbiological
Product number
257298
Product name
Erythromycin stearate
Packaging
50g
Price
$307
Updated
2021/12/16
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Erythromycin stearate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Erythrocin Stearate,Abbott,US,1952

Uses

Semi-synthetic macrolide antibiotic. Antibacterial

Uses

oil lubricant, plasticizer, solvent

Uses

Macrodiles antibacterial

Definition

ChEBI: Erythromycin stearate is an aminoglycoside.

Manufacturing Process

To a well-stirred solution of 3.18 grams (10.5 mmol) of stearoyl chloride and 1.24 grams (11.0 mmol) of 1-ethylpiperidine in 50 ml of methylene chloride is added 7.20 grams (10.0 mmol) of erythromycin. After a short time complete solution is obtained and stirring is then discontinued. The solution is allowed to stand overnight. The solution is diluted to 250 ml by the addition of methylene chloride and washed three times with 100 ml portions of water followed by two washes with 5% sodium bicarbonate solution. The organic layer is dried over anhydrous sodium sulfate and filtered, the solvent being removed under diminished pressure. The product is dried to constant weightat room temperature in a vacuum desiccator.

brand name

Bristamycin (Bristol-Myers Squibb); Erythrocin (Abbott).

Therapeutic Function

Antibacterial

General Description

Erythromycin stearate (Ethril, Wyamycin S, Erypar) is thestearic acid salt of erythromycin. Like erythromycin base,the stearate is acid labile. It is film coated to protect it fromacid degradation in the stomach. In the alkaline pH of theduodenum, the free base is liberated from the stearateand absorbed. Erythromycin stearate is a crystalline powderthat is practically insoluble in water but soluble in alcoholand ether.

General Description

Fluffy colorless powder or fine white powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A base. Readily forms salts with acids.

Fire Hazard

Flash point data for Erythromycin stearate are not available; however, Erythromycin stearate is probably combustible.

Erythromycin stearate Preparation Products And Raw materials

Raw materials

Stearic acid

Preparation Products

Complex heat stabilizer PVC composite stabilizer
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Erythromycin stearate Suppliers

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View Lastest Price from Erythromycin stearate manufacturers

Hebei Guanlang Biotechnology Co., Ltd.
Product
Erythromycin stearate 643-22-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-09-01
Shaanxi Dideu Medichem Co. Ltd
Product
Erythromycin stearate 643-22-1
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-07
Hebei Mojin Biotechnology Co., Ltd
Product
Erythromycin stearate 643-22-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-31

643-22-1, Erythromycin stearate Related Search:

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