Isoprinosine

ChemicalBook > CAS DataBase List > Isoprinosine

Description Sources

Product Name: Isoprinosine
CAS No.: 36703-88-5
Chemical Name: Isoprinosine
Synonyms: methisoprinol;np113;0.8um;aviral;)(1:3);0.22um;0.45um;viruxan;imunovir;delimmun
CBNumber: CB2437987
Molecular Formula: C24H34N6O9
Formula Weight: 550.57
MOL File: 36703-88-5.mol

Less

Isoprinosine Property

Melting point:: 140-142°C
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
form: Solid
color: White to Off-White
Merck: 14,4976
InChI: InChI=1/C10H12N4O5.C9H9NO3.C5H13NO/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18;1-6(11)10-8-4-2-7(3-5-8)9(12)13;1-5(7)4-6(2)3/h2-4,6-7,10,15-17H,1H2,(H,11,12,18);2-5H,1H3,(H,10,11)(H,12,13);5,7H,4H2,1-3H3/t4-,6-,7-,10-;;/s3
InChIKey: PBJNZCQJMWVIRT-JHVGCDEENA-N
SMILES: O[C@@H]1[C@@H]([C@@H](CO)O[C@H]1N1C=NC2C(N=CNC1=2)=O)O.C(N(C)C)C(O)C.N(C1C=CC(C(=O)O)=CC=1)C(=O)C |&1:1,2,3,7,r|

Less

Safety

HS Code: 2934.99.9001
Toxicity: LD50 in mice and rats (mg/kg): >4000 orally and i.p. (Gordon)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: I1037
Product name: Inosine Pranobex
Purity: >98.0%(HPLC)(T)
Packaging: 100mg
Price: $29
Updated: 2024/03/01

TCI Chemical

Product number: I1037
Product name: Inosine Pranobex
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 16492
Product name: Isoprinosine
Purity: ≥98%
Packaging: 10mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16492
Product name: Isoprinosine
Purity: ≥98%
Packaging: 1g
Price: $595
Updated: 2024/03/01

Cayman Chemical

Product number: 16492
Product name: Isoprinosine
Purity: ≥98%
Packaging: 50mg
Price: $130
Updated: 2024/03/01

Less

Isoprinosine Chemical Properties,Usage,Production

Description

ISOPRINOSINE (also known as inosine pranobex) an antiviral drug combing of inosine and dimepranol acedoben (a salt of acetamidobenzoic acid and dimethylaminoisopropanol) in a ratio of 1 to 3. It is mainly used for treating the rare measles complication subacute sclerosing panencephalitis in conjunction with intrathecal interferon therapy^1,2. In UK, it is also indicated for mucocutaneous infections due to herpes simplex virus (type 1 and type 2) and for treatment of genital warts as adjunctive therapy to podophyllin or carbon dioxide laser1. It also has certain efficacy in the treatment of AIDS and some other acquired immunodeficiency such as aged patients, cancer patients, severely burned patients, ill patients, and surgery patients³. Preclinical studies have demonstrated that isoprinosine can inhibit the growth of both DNA and RNA viruses as well as potentiate cell-mediated immune response both in vitro and in vivo^4,5.

Sources

https://en.wikipedia.org/wiki/Inosine_pranobex
Waldman, R. H., and R. Ganguly. "Therapeutic efficacy of inosiplex (Isoprinosine) in rhinovirus infection. " Annals of the New York Academy of Sciences 284.1(1977):153–160.
https://www.ncbi.nlm.nih.gov/pubmed/2446760
https://www.ncbi.nlm.nih.gov/pubmed/83189
https://www.drugbank.ca/drugs/DB13156

Chemical Properties

White powder, odorless and tasteless. Soluble in water.

Uses

Isoprinosine is a new combination of active substances for the treatment of chronic systemic diseases such as cancer. Isoprinosine is an immunomodulator; antiviral. The ratio is between 1: 2 : 2 to 1 : 3 : 3

Biological Activity

isoprinosine is a complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio with immunomodulatory effects.immunotherapy is the treatment of disease by inducing, enhancing, or suppressing an immune response. immunomodulatory regimens usually have fewer side effects than existing drugs, such as less potential for creating resistance when treating microbial disease.

Mechanism of action

Isoprinosine is thought to act through a receptor for an inosine-like compound on T cell precursors. In vivo it appears to induce the production of more mature T cells and there is some evidence that it can increase the CD4:CD8 ratio in a variety of conditions. In addition, Isoprinosine enhances B-lymphocyte activity, possibly through effects on helper T cells. It also increases macrophage phagocytosis, releases cytokines that induce macrophage proliferation, including immune interferon and interleukin-1 (IL-1) and IL-2, and potentiates T-cell mitogens.

Clinical Use

Treatment of mucocutaneous herpes simplex, genital warts, subacute sclerosing panencephalitis

in vitro

previous study found that increasing concentrations of isoprinosine (50-400 μg/ml) could produce progressively growing inhibitory effect on hhv-1 replication. the combination of 1000 iu/ml ifn-α and isoprinosine could result in enhanced anti-hhv activity [1].

in vivo

previous study demonstrated the positive effect of isoprinosine treatment on persistent infection of balb/c mice with murine gammaherpesvirus 68. increased number of leukocytes, increased percentage of neutrophils, elevated levels of virus-neutralizing antibodies, reduced number of atypical lymphocytes and reduced virus titers were detected in the examined organs after a 14-day treatment. the positive effect of isoprinosine therapy vanished after 120-150 days [2].

Metabolism

Hepatically metabolised. The major excretion product of the inosine moiety is uric acid, while the p-acetamidobenzoic acid and N,N-dimethylamino- 2-propanol components are excreted in the urine as glucuronidated and oxidised products, respectively, as well as being excreted unchanged

References

[1] majewska a, lasek w, janyst m, mynarczyk g. in vitro infibition of hhv-1 replication by inosine pranobex and interferon-α. acta pol pharm. 2016 may-jun;73(3):637-44.
[2] janíková o, anicová l, briestenská k, mistríková j. the effect of isoprinosine treatment on persistent infection of balb/c mice infected with murine gammaherpesvirus 68. acta virol. 2017;61(1):32-38. doi: 10.4149/av_2017_01_32.
[3] beran j, alapová e, pajdel m; isoprinosine study (ewo iso-2014/1) team. inosine pranobex is safe and effective for the treatment of subjects with confirmed acute respiratory viral infections: analysis and subgroup analysis from a phase 4, randomised, placebo-controlled, double-blind study. bmc infect dis. 2016 nov 7;16(1):648.

Isoprinosine Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Isoprinosine Suppliers

Americas 1 Belgium 1 Canada 1 China 329 Czech Republic 2 Europe 1 Germany 3 India 11 Italy 1 Japan 1 Poland 1 South Korea 1 Spain 1 Switzerland 1 United Kingdom 1 United States 20 Global 376

Watson Biotechnology Co.,Ltd

Tel: 027-59207879 1972026995 18140587686
Fax: QQ：1972026995
Email: sales@3600chem.com
Country: China
ProdList: 4668
Advantage: 55

Hubei Yihao Biotechnology Co., Ltd.

Tel: 18995688786 18995688786
Email: 156716255@qq.com
Country: China
ProdList: 260
Advantage: 58

Wuhan Juchengyuan Biotechnology Co., Ltd

Tel: 400-027-6007 18062142210
Email: 804180422@qq.com
Country: China
ProdList: 143
Advantage: 58

Shandong Jihao Biotechnology Co., Ltd.

Tel: 0531-69958659 15668363232
Email: 8598038@qq.com
Country: China
ProdList: 45
Advantage: 58

Hubei Baoling Chemical Technology Co. , Ltd.

Tel: 13129969326
Email: 2797487194@qq.com
Country: China
ProdList: 1007
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Wuhan Wei Shunda Technology Development Co., Ltd.

Tel: 86-027-88774375
Fax: 86-027-88416321
Email: mwmwhot@163.com
Country: China
ProdList: 233
Advantage: 65

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8843
Advantage: 52

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Wuhan Kemi-Works Chemical Co., Ltd

Tel: 027-85736489
Fax: 86-27-85736485
Email: info@kemiworks.net
Country: China
ProdList: 540
Advantage: 57

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4552
Advantage: 62

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9545
Advantage: 55

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Wuhan DKY Technology Co.,Ltd.

Tel: 27-81302488 18007166089
Fax: 027-81302088
Email: info@dkybpc.com
Country: China
ProdList: 2024
Advantage: 58

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3120
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Changzhou josenchem Pharmaceutical Chemical Material Co.,Ltd.

Tel: 519-519-85286950 13338194135
Fax: 0519-85286950
Email: info@josenchem.com
Country: China
ProdList: 75
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9648
Advantage: 58

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4943
Advantage: 58

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Qufu Haida Tiancheng Biochemical Co., Ltd.

Tel: 0537-4531868 18553729317
Email: hdchem@126.com
Country: China
ProdList: 88
Advantage: 55

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

Hubei Kangbaotai Finechem Co., Ltd.

Tel: +86 (27) 8778653
Fax: +86 (27) 8773-8652
Email: 13720228325@163.com
Country: China
ProdList: 337
Advantage: 58

Wuhu Nuowei Chemical Technology Co., Ltd

Tel: 0553-8233716 18055326116
Email: sales@nuowei-chem.com
Country: China
ProdList: 951
Advantage: 55

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: sales@chemwill.com
Country: China
ProdList: 1974
Advantage: 58

Hangzhou Dingyan Chem Co., LTD

Tel: 0571-87157530-8002 15267169049
Fax: 0571-87156470
Email: sales@dingyanchem.com
Country: China
ProdList: 2190
Advantage: 58

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Changzhou Josen Pharmaceutical Chemical Material Co., Ltd.

Tel: 18961143913
Fax: 0519-85286950
Email: 444964576@qq.com
Country: China
ProdList: 56
Advantage: 58

Wuxi Jingyao Bio-Technology Co., Ltd.

Tel: 0510-88770633 13961738808
Email: jingyaobiotech@126.com
Country: China
ProdList: 323
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27313
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Shijiazhuang XinZhaoYang Chemical Technology Co., Ltd.

Tel: 0311-69032540 13931172911
Fax: 0311-69032540
Email: 2636239065@qq.com
Country: China
ProdList: 289
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10009
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

Shenzhen Simeiquan Biotechnology Co. Ltd

Tel: 18126413629 0755-23311925 2355327053
Fax: 0755-23311925
Email: abel@ycgmp.com
Country: China
ProdList: 5113
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-83991130 18627774460
Fax: 027-83991130
Email: 1718093273@QQ.COM
Country: China
ProdList: 1881
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13320
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Less

View Lastest Price from Isoprinosine manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Inosine pranobex 36703-88-5
Price: US $0.00-0.00/g
Min. Order: 10000g
Purity: 99% HPLC
Supply Ability: 1000kg
Release date: 2024-11-21

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Isoprinosine 36703-88-5
Price: US $0.00/kg
Min. Order: 25kg
Purity: 99.0%
Supply Ability: 1tons
Release date: 2024-04-26

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Isoprinosine 36703-88-5
Price: US $0.00/KG
Min. Order: 25KG
Purity: 95.0%-105.0%
Supply Ability: 500kg/month
Release date: 2021-05-31

36703-88-5, IsoprinosineRelated Search:

Aluminium isopropoxide Sodium propan-2-olate 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Ethopabate IPTG Shikimic acid Ribavirin Acyclovir Polyinosinic acid-polycytidylic acid 1-Dimethylamino-2-propanol Inosine Isoprinosine

ISOPRINOSINE

)(1:3)

aviral

delimmun

imunovir

inosine,compd.with1-(dimethylamino)-2-propanol4-(acetylamino)benzoate(salt

inosinepranobex

inosiplex

isoprinosin

isoviral

Isopranosine

MethisoprinoluM (Inosine pranobex)

inosine, compound with (2-hydroxypropyl)dimethylammonium p-acetamidobenzoate (1:3)

Isoprinosine(Methisoprinol)

methisoprinol

np113

ntp10381

viruxan

Nitroglycerin Solution Impurity II:Glycerol 1,3-dinitrate solution

9-[(2r,3r,4r,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one

Groprinosin

Immunovir

nosine pranobex

Isoprinosine (Inosine Pranobex)

4-Acetamidobenzoic acid,9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one,1-(Dimethylamino)propan-2-ol (3:1:3)

Indosine Pranobeox

ISOPRINOSINE USP/EP/BP

Inosin, Verbindung mit (2-Hydroxypropyl)dimethylammonium-p-acetamidobenzoat (1:3)

Indosine Pranobeox,Inosiplex,Methisoprinol,

Isopropyl inosine

0.22um

0.45um

0.8um

Inosine pranobex (Imunovir

Metisoprinol

Isoprinosina

Inosine, compd. with 1-(dimethylamino)-2-propanol4-(acetylamino)benzoate (salt) (1:3)OTHER CA INDEX NAMES:2-Propanol, 1-(dimethylamino)-, 4-(acetylamino)benzoate (salt),compd. with inosine (3:1)Benzoic acid, 4-(acetylamino)-, compd. with1-(dimethylamino)-2-propanol and inosine (3:3:1)

36703-88-5

36703-88-3

C10H12N4O53C9H9NO33C5H13NO

C52H78N10O17

36703-88-5