ChemicalBook > CAS DataBase List > 5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE

5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE

Product Name: 5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE
CAS No.: 4053-45-6
Chemical Name: 5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE
Synonyms: SKL220;Nsc83066;Aids125750;Aids-125750;TIMTEC-BB SBB000700;IFLAB-BB F2124-0006;5-(Chloromethyl)-8-quinolinol;8-quinolinol, 5-(chloromethyl)-;5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE;5-(CHLOROMETHYL)QUINOLIN-8-OL HYDROCHLORIDE
CBNumber: CB2440976
Molecular Formula: C10H9Cl2NO
Formula Weight: 230.09
MOL File: 4053-45-6.mol

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5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE Property

Melting point:: 280 °C (decomp)
storage temp.: 2-8°C
EPA Substance Registry System: 8-Quinolinol, 5-(chloromethyl)-, hydrochloride (1:1) (4053-45-6)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B419278
Product name: 5-(Chloromethyl)quinolin-8-olHydrochloride
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC120157
Product name: 5-(Chloromethyl)quinolin-8-ol hydrochloride
Packaging: 250mg
Price: $85
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC120157
Product name: 5-(Chloromethyl)quinolin-8-ol hydrochloride
Packaging: 500mg
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC120157
Product name: 5-(Chloromethyl)quinolin-8-ol hydrochloride
Packaging: 1g
Price: $255
Updated: 2021/12/16

Matrix Scientific

Product number: 060183
Product name: 5-(Chloromethyl)quinolin-8-ol hydrochloride
Packaging: 500mg
Price: $260
Updated: 2021/12/16

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5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE Chemical Properties,Usage,Production

Synthesis

148-24-3

50-00-0

4053-45-6

14.6 g (0.1 mol) of 8-hydroxyquinoline, 16 mL of 32% aqueous hydrochloric acid and 16 mL (0.1 mol) of 37% aqueous formaldehyde were mixed at 0°C and passed through hydrogen chloride gas to react for 6 hours. After completion of the reaction, the mixture was allowed to stand at room temperature for 2 hours without stirring. The yellow solid produced by the reaction was collected by filtration, washed with 90% ethanol and dried under vacuum to afford 5-(chloromethyl)-8-quinolinol hydrochloride (19.0 g, 98% yield). The structure of the product was confirmed by 1H NMR (250 MHz, CDCl3): δ 5.32 (s, 2H), 7.53 (m, 1H), 7.85 (m, 2H), 8.12 (m, 1H), 9.12 (m, 1H), 9.28 (m, 1H).

References

[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 24, p. 10455 - 10463
[2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 3, p. 773 - 783
[3] Patent: WO2012/20389, 2012, A1. Location in patent: Page/Page column 22
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 21, p. 8616 - 8637
[5] Journal of Molecular Liquids, 2016, vol. 219, p. 396 - 404

5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE Suppliers

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View Lastest Price from 5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-(Chloromethyl)-8-quinolinol 4053-45-6
Price: US $30.00-20.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-07-30

Henan Fengda Chemical Co., Ltd

Product: 5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE 4053-45-6
Price: US $8.00-0.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-28

Career Henan Chemical Co

Product: 5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE 4053-45-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

4053-45-6, 5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDERelated Search:

8-HYDROXYQUINOLINE HYDROCHLORIDE

5-(Chloromethyl)-8-hydroxyquinoline hydrochloride

8-quinolinol, 5-(chloromethyl)-

5-(Chloromethyl)-8-quinolinol

8-Quinolinol, 5-(chloromethyl)-, hydrochloride

Aids125750

Aids-125750

Nsc83066

5-(CHLOROMETHYL)QUINOLIN-8-OL HYDROCHLORIDE

5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE

IFLAB-BB F2124-0006

TIMTEC-BB SBB000700

5-(Chloromethyl)quinolin-8-ol hydrochloride (1:1)

SKL220

4053-45-6

C10H8ClNOHCl

C10H8ClNOClH