ChemicalBook > CAS DataBase List > 15(R)-15-METHYL PROSTAGLANDIN D2
15(R)-15-METHYL PROSTAGLANDIN D2
- Product Name
- 15(R)-15-METHYL PROSTAGLANDIN D2
- CAS No.
- 210978-26-0
- Chemical Name
- 15(R)-15-METHYL PROSTAGLANDIN D2
- Synonyms
- CTXLUMAOXBULOZ-BKVRKCTKSA-N;15(R)-15-METHYL PROSTAGLANDIN D2;15(R)-15-methyl Prostaglandin D2;15(R)-15-methyl Prostaglandin D2 Exclusive;9a,15R-Dihydroxy-11-oxo-15-methylprosta-5Z,13E-dien-1-oic acid;9ALPHA,15R-DIHYDROXY-11-OXO-15-METHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID;Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-15-methyl-11-oxo-, (5Z,9α,13E,15R)-
- CBNumber
- CB2445810
- Molecular Formula
- C21H34O5
- Formula Weight
- 366.49
- MOL File
- 210978-26-0.mol
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15(R)-15-METHYL PROSTAGLANDIN D2 Property
- storage temp.
- −20°C
- solubility
- DMF: >100 mg/ml; DMSO: >50 mg/ml; Ethanol: >75 mg/ml; PBS (pH 7.2): >5 mg/ml
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Safety
- Hazard Codes
- T
- Risk Statements
- 60-22
- Safety Statements
- 53-22-26-36
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 12720
- Product name
- 15(R)-15-methyl Prostaglandin D2
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $78
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 12720
- Product name
- 15(R)-15-methyl Prostaglandin D2
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $132
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 12720
- Product name
- 15(R)-15-methyl Prostaglandin D2
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $485
- Updated
- 2022/04/27
American Custom Chemicals Corporation
- Product number
- BIO0000264
- Product name
- (Z)-7-[(1R,2S,5S)-5-HYDROXY-2-[(E,3R)-3-HYDROXY-3-METHYL-OCT-1-ENYL]-3-OXO-CYCLOPENTYL]HEPT-5-ENOICACID
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $194.25
- Updated
- 2021/12/16
AK Scientific
- Product number
- 1206AH
- Product name
- 15(R)-15-MethylprostaglandinD2
- Packaging
- 1mg
- Price
- $251
- Updated
- 2021/12/16
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15(R)-15-METHYL PROSTAGLANDIN D2 Chemical Properties,Usage,Production
Uses
15(R)-15-Methyl prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1and CRTH2/DP2. 15(R)-15-Methyl prostaglandin D2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 μM.
Definition
ChEBI: 15-methyl-15R-PGD2 is a prostanoid.
References
[1] Hayaishi, et al. Sleep-wake regulation by prostaglandins D2 and E2. J. Biol. Chem. 263(29), 14593-14596 (1988).
15(R)-15-METHYL PROSTAGLANDIN D2 Preparation Products And Raw materials
Raw materials
Preparation Products
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