4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate

Product Name: 4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate
CAS No.: 522649-59-8
Chemical Name: 4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate
Synonyms: Malic Enzyme inhibitor ME1;Malic Enzyme inhibitor ME1 (ME1);Malic enzyme inhibitor ME1, 10 mM in DMSO;Malic enzyme inhibitor ME1 (Synonyms: ME1);3-(4-(4-Hydroxyphenyl)piperazin-1-yl)-1-phenylpyrrolidine-2,5-dione;2,5-Pyrrolidinedione, 3-[4-(4-hydroxyphenyl)-1-piperazinyl]-1-phenyl-;4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate
CBNumber: CB24489436
Molecular Formula: C20H21N3O3
Formula Weight: 351.4
MOL File: 522649-59-8.mol

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4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Property

Boiling point:: 638.1±55.0 °C(Predicted)
Density: 1.342±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 125 mg/mL (355.72 mM)
form: Solid
pka: 12.18±0.30(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC12536
Product name: MalicEnzymeinhibitorME1
Purity: >98%
Packaging: 1g
Price: $2100
Updated: 2021/12/16

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4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Chemical Properties,Usage,Production

Uses

Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM[1][2].

Biological Activity

Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent malic enzyme (ME1) inhibitor with IC50 of 0.15 μM.

in vitro

Malic enzyme inhibitor ME1 (ME1; ME1*) (50 μM; 72 hours) shows a significant reduction in total cell numbers.
It shows a significant reduction in cell viability/metabolic activity in MTS cell.
It dose-dependently reduces the number of colonies formed by both HCT116 and HT29 cells.

Cell Viability Assay

Cell Line:	HCT116 and HT29 cell line
Concentration:	50 μM
Incubation Time:	72 hours
Result:	Showed a significant reduction in total cell numbers.

target

IC50: 0.15 μM (Malic enzyme)

References

[1] Zhang YJ, et al. In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors. Bioorg Med Chem Lett. 2006 Feb;16(3):525-8. Epub 2005 Nov 8. DOI:10.1016/j.bmcl.2005.10.065
[2] Fernandes L, et al. Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice. Sci Rep. 2018 Sep 24;8(1):14268. DOI:10.1038/s41598-018-32532-w

4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Suppliers

China 26 Finland 2 United States 4 Global 32

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522649-59-8, 4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolateRelated Search:

4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate

Malic Enzyme inhibitor ME1

2,5-Pyrrolidinedione, 3-[4-(4-hydroxyphenyl)-1-piperazinyl]-1-phenyl-

Malic enzyme inhibitor ME1 (Synonyms: ME1)

Malic enzyme inhibitor ME1, 10 mM in DMSO

3-(4-(4-Hydroxyphenyl)piperazin-1-yl)-1-phenylpyrrolidine-2,5-dione

Malic Enzyme inhibitor ME1 (ME1)

522649-59-8