3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- Product Name
- 3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- CAS No.
- 53090-43-0
- Chemical Name
- 3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- Synonyms
- ETHYL (3,4-DICHLOROBENZOYL)ACETATE;Ethyl 2-(3,4-dichlorobenzoyl)acetate;Ethyl 3,4-dichloro-β-oxobenzenepropanoate;Ethyl 3-(3,4-dichlorophenyl)-3-oxopropionate;ETHYL 3-(3,4-DICHLOROPHENYL)-3-OXOPROPANOATE;Benzenepropanoic acid, 3,4-dichloro-β-oxo-, ethyl ester;Benzenepropanoic acid, 3,4-dichloro-b-oxo-, ethyl ester;3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER;3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER ISO 9001：2015 REACH
- CBNumber
- CB2450595
- Molecular Formula
- C11H10Cl2O3
- Formula Weight
- 261.1
- MOL File
- 53090-43-0.mol
3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Property
- Boiling point:
- 357.6±32.0 °C(Predicted)
- Density
- 1.319
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.62±0.48(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 7523AB
- Product name
- Ethyl3-(3,4-dichlorophenyl)-3-oxopropanoate
- Packaging
- 250mg
- Price
- $139
- Updated
- 2021/12/16
- Product number
- HCH0320363
- Product name
- ETHYL 3-(3,4-DICHLOROPHENYL)-3-OXOPROPANOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.47
- Updated
- 2021/12/16
- Product number
- CM132326
- Product name
- ethyl3-(3,4-dichlorophenyl)-3-oxopropanoate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1122
- Updated
- 2021/12/16
- Product number
- 53090430
- Product name
- Ethyl3-(3,4-dichlorophenyl)-3-oxopropanoate
- Packaging
- 5g
- Price
- $1248
- Updated
- 2021/12/16
- Product number
- OP-0138
- Product name
- Ethyl3-(3,4-dichlorophenyl)-3-oxopropanoate
- Purity
- 97%
- Packaging
- 0.5g
- Price
- $91.67
- Updated
- 2021/12/16
3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Uses
Ethyl 3-(3,4-dichlorophenyl)-3-oxopropionate is an organic intermediate, which has been reported in the literature to prepare α-ketoamides and their derivatives.
Preparation
React with 3,4-dichlorobenzaldehyde, ethyl diazoacetate and ter-BuOK, and then directly separate the resulting mixture by silica gel flash column chromatography to obtain Ethyl 3-(3,4-dichlorophenyl)-3-oxopropionate.
Synthesis
51-44-5
6148-64-7
53090-43-0
1. CDI (41.5 g, 290.32 mmol, 3.70 eq.) was added to a solution of 3,4-dichlorobenzoic acid (15 g, 78.53 mmol, 1.00 eq.) in tetrahydrofuran (200 mL) under dry conditions. The reaction mixture was stirred at 25 °C for 4 hours. 2. In another reaction flask, monoethyl malonate potassium salt (37.7 g, 235 mmol, 3.00 eq.) was dissolved in acetonitrile (400 mL), followed by the addition of MgCl2 (33.5 g, 353 mmol, 4.5 eq.) and triethylamine (23.8 g, 235 mmol, 3.00 eq.). 3. The solutions from Steps 1 and 2 were combined and the reaction was stirred at room temperature for 2 hours. 4. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. 5. The concentrated residue was diluted with 200 mL of water and the pH was adjusted to 5 with 1 M HCl. 6. The aqueous phase was extracted with ethyl acetate (4 x 50 mL), the organic layers were combined and dried with anhydrous magnesium sulfate. 7. After filtering the desiccant, the organic phase was concentrated under reduced pressure. 8. The crude product was purified by silica gel column chromatography using petroleum ether/ethyl acetate (50:1) as eluent. 9. 15 g (73% yield) of ethyl 3-(3,4-dichlorophenyl)-3-oxopropanoate was finally obtained as a colorless oil.
References
[1] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175
3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 021-58388037;21-58388037 13472507714
- 35177634@qq.com;1589045147@qq.com
- Country
- China
- ProdList
- 803
- Advantage
- 55
- Tel
- 0512-56316828 4008675858
- Fax
- +86-512-56316826
- sales@amateksci.com
- Country
- China
- ProdList
- 9874
- Advantage
- 55
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 0371-88888888 272369594
- Fax
- QQ:272369594
- 2723695949@qq.com
- Country
- China
- ProdList
- 4962
- Advantage
- 50
- Tel
- 0512-63009836 18994340901
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3981
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-66162170
- Fax
- 025-66162170
- Country
- China
- ProdList
- 7181
- Advantage
- 55
- Tel
- 025-58859352 18068836627
- Fax
- (5)02557626880
- dt3@aikonchem.com
- Country
- China
- ProdList
- 15493
- Advantage
- 58