4-(2-CHLORO-PHENYL)-THIAZOL-2-YLAMINE

4-(2-CHLORO-PHENYL)-THIAZOL-2-YLAMINE Property

Melting point:

132-138°C

Boiling point:

371.1±17.0 °C(Predicted)

Density 

1.389±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

Solid

pka

4.15±0.50(Predicted)

Appearance

White to yellow Solid

Safety

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2934100090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P403Store in a well-ventilated place.

4-(2-CHLORO-PHENYL)-THIAZOL-2-YLAMINE Chemical Properties,Usage,Production

Synthesis

The general procedure for the synthesis of 4-(2-chlorophenyl)-1,3-thiazol-2-amine from o-chloroacetophenone and the compound (CAS:17356-08-0) was as follows: firstly, 2'-chloroacetophenone (0.05 mol), iodine (0.1 mol), and thiourea (0.1 mol) were mixed in a small conical flask and ground thoroughly using a mortar and pestle until homogeneous (reaction 1). Subsequently, the mixture was placed in a microwave reactor and radiated at 180 W power for 5 min, during which time it was paused every 30 sec. Upon completion of the reaction, 100 mL of distilled water was added to the mixture and microwave heating was continued at 270 W power for 5-6 min, with pauses at 1 min intervals to ensure complete dissolution of the precipitate. The reaction solution was cooled and filtered to obtain a yellow filtrate. The filtrate was adjusted to alkaline with ammonia solution to precipitate the target product. The product was separated by filtration, purified by recrystallization with ethanol and ether successively, and finally dried under reduced pressure to give 4-(2-chlorophenyl)-1,3-thiazol-2-amine.

References

[1] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2013, vol. 115, p. 393 - 398
[2] Chemical and Pharmaceutical Bulletin, 2007, vol. 55, # 7, p. 1014 - 1017
[3] Journal of Heterocyclic Chemistry, 2002, vol. 39, # 6, p. 1133 - 1138
[4] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 305 - 313
[5] Arzneimittel-Forschung/Drug Research, 1986, vol. 36, # 9, p. 1391 - 1393