2-(2-Methylpropyl)pyridine

Product Name: 2-(2-Methylpropyl)pyridine
CAS No.: 6304-24-1
Chemical Name: 2-(2-Methylpropyl)pyridine
Synonyms: FEMA 3370;FEMA NUMBER 3370;2-ISOBUTYLPYRIDINE;2-(2-METHYLPROPYL) PYRIDINE;Pyridine, 2-(2-methylpropyl)-
CBNumber: CB2454285
Molecular Formula: C9H13N
Formula Weight: 135.21
MOL File: 6304-24-1.mol

More

Less

2-(2-Methylpropyl)pyridine Property

Boiling point:: 180-185 °C
Density: 0.899
FEMA: 3370 | 2-(2-METHYLPROPYL)PYRIDINE
storage temp.: Inert atmosphere,Room Temperature
pka: 5.83±0.19(Predicted)
Odor: at 0.10 % in dipropylene glycol. strong aromatic bell pepper
Odor Type: aromatic
JECFA Number: 1311
LogP: 2.60
CAS DataBase Reference: 6304-24-1(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TRC

Product number: I786523
Product name: 2-Isobutylpyridine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: FFG0002826
Product name: 2-ISOBUTYLPYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $503.9
Updated: 2021/12/16

Crysdot

Product number: CD11084107
Product name: 2-Isobutylpyridine
Purity: 95+%
Packaging: 25g
Price: $398
Updated: 2021/12/16

AHH

Product number: MT-16007
Product name: 2-Isobutylpyridine
Purity: 99%
Packaging: 100g
Price: $455
Updated: 2021/12/16

Chemenu

Product number: CM173984
Product name: 2-Isobutylpyridine
Purity: 95%
Packaging: 10g
Price: $210
Updated: 2021/12/16

More

Less

2-(2-Methylpropyl)pyridine Chemical Properties,Usage,Production

Description

May be prepared from 2-pycolyllithium and isopropyl bromide; from 2-methyl pyridine and isopropyl bromide in liquid ammonia in the presence of potassium metal and ferric nitrate.

Preparation

From β-picoline with NaNH2 and alkyl chloride or bromide.

Definition

ChEBI: 2-(2-Methylpropyl)pyridine is a member of pyridines.

Synthesis

100-71-0

823-96-1

622-39-9

6304-24-1

The methylation reaction was carried out by General Method 2 using 2-ethylpyridine and trimethylcyclotriboroxane as raw materials. Upon completion of the reaction, the products were purified by column chromatography to give two products: 21 (2-propylpyridine) as a colorless oil (19.1 mg, 79% yield) and 13a (2-isobutylpyridine) as a colorless oil (3.0 mg, 11% yield). The NMR data for 21 (2-propylpyridine) are as follows: 1H NMR (400 MHz, CDCl3) δ 8.53 (d, J = 4.8 Hz, 1H), 7.58 (td, J = 7.6, 1.6 Hz, 1H), 7.14 (d, J = 8.0 Hz, 1H), 7.11-7.08 (m, 1H), 2.77 (t, J = 7.6 Hz, 2H), 1.81-1.71 (m, 2H), 0.97 (t, J = 7.2 Hz, 3H). 13C NMR (100 MHz, CDCl3) δ 162.35, 149.26, 136.25, 122.83, 120.94, 40.49, 23.19, 13.94; HRMS (EI): calculated value C8H11N (M+) 121.0891, measured value 121.0893. The NMR data of 13a (2-isobutylpyridine) are as follows: 1H NMR (400 MHz, CDCl3) δ 8.53 (d, J = 4.4 Hz, 1H), 7.58 (td, J = 7.6, 1.6 Hz, 1H), 7.12-7.08 (m, 2H), 2.65 (d, J = 7.6 Hz, 2H), 2.15-2.05 (m, 1H), 0.93 (d, J = 6.8 Hz, 6H); 13C NMR (100 MHz). 13C NMR (100 MHz, CDCl3) δ 161.89, 149.50, 136.34, 123.81, 121.19, 47.93, 29.57, 22.74; HRMS (EI): calculated value C9H13N (M+) 135.1048, measured value 135.1046. Reaction conditions: in a 40 mL reaction tube, the substrate (0.2 mmol, 1 eq.), Pd(OAc)2 (4.5 mg, 0.02 mmol, 10 mol%), methyl cycloboroxane (55.7 μL, 0.4 mmol, 2 eq.), Cu(OAc)2 (72.8 mg, 0.4 mmol, 2 eq.) and benzoquinone (43.2 mg, 0.4 mmol, 2 eq.) were mixed together. 0.4 mmol, 2 eq.) were dissolved in 1 mL of acetic acid and reacted under oxygen atmosphere. The reaction tube was sealed with a PTFE-lined cap and the reaction mixture was stirred at 100 °C for 24 hours. After completion of the reaction, it was neutralized to pH=8-9 with 4N NaOH aqueous solution and then treated with 10 mL of saturated Na2S aqueous solution. The mixture was filtered through a diatomaceous earth pad and the diatomaceous earth was washed with 20 mL of dichloromethane. The filtrate was washed twice with saturated brine and the organic layer was dried with Na2SO4 and concentrated in vacuum. The residue was purified by silica gel column chromatography (eluent: hexane:ether=10:1) to give the methylated product.

References

[1] Journal of the American Chemical Society, 2006, vol. 128, # 39, p. 12634 - 12635
[2] Patent: WO2008/24953, 2008, A2. Location in patent: Page/Page column 6; 62; 67-68
[3] Patent: WO2008/24953, 2008, A2. Location in patent: Page/Page column 6; 62; 67-68

2-(2-Methylpropyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-(2-Methylpropyl)pyridine Suppliers

China 34 Germany 2 India 1 United Kingdom 8 United States 17 USA 1 Global 63

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Shaanxi Dideu Newmaterial Co., Ltd.

Tel: 029-63373950 17392213970
Email: 1052@dideu.com
Country: China
ProdList: 9998
Advantage: 58

Jiaxing Deyi Chemical Co., Ltd

Tel: 0573-85866609 13588473046
Email: 824930988@qq.com
Country: China
ProdList: 7865
Advantage: 58

Shanghai Haohong Scientific Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Zhuhai Aobokai Biomedical Technology Co., Ltd.

Tel: 400-0628126 15697567703
Email: sales-team@aobchem.com.cn
Country: China
ProdList: 49999
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.

Tel: +8618950047208
Email: ellena@amitychem.com
Country: China
ProdList: 43416
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49937
Advantage: 58

PT CHEM GROUP LIMITED

Tel: +86-85511178;
Email: peter68@ptchemgroup.com
Country: China
ProdList: 35425
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Tengzhou Wutong Spice Co., Ltd.

Tel: --
Fax: --
Email: genian.shan@wu-tong.com
Country: CHINA
ProdList: 364
Advantage: 58

Anhui Haibei Import & Export Co., Ltd.

Tel: --
Fax: --
Email: info@haibeiflavor.com
Country: China
ProdList: 365
Advantage: 30

Hefei Silver Sail Import and Export Trade Co., Ltd.,

Tel: --
Fax: --
Email: hfss@ahhfss.com
Country: China
ProdList: 185
Advantage: 30

Xiamen Bestally Imp. & Exp. Co., Ltd

Tel: --
Fax: --
Email: zhang@bestally.com.cn
Country: China
ProdList: 236
Advantage: 62

Shanghai PI Chemicals Ltd.

Tel: --
Fax: --
Email: sales@pipharm.com
Country: China
ProdList: 6344
Advantage: 56

Guangzhou WeiBo Chemical Co., Ltd.

Tel: --
Fax: --
Email: weibochem@163.com
Country: China
ProdList: 6187
Advantage: 67

DAMING CHANGDA CO.,LTD

Tel: --
Fax: --
Email: joelee@changdapharm.com
Country: China
ProdList: 5640
Advantage: 30

DSL Chemicals Co.，Ltd

Tel: --
Fax: --
Email: info@DSLChem.com
Country: China
ProdList: 6983
Advantage: 65

Advanced Technology & Industrial Co., Ltd.

Tel: --
Fax: --
Email: sales@advtechind.com
Country: China
ProdList: 6523
Advantage: 75

Shanghai FWD Chemicals Co., Ltd.

Tel: --
Fax: --
Email: sales@fwdchem.com
Country: China
ProdList: 6927
Advantage: 58

Shanghai M & U International Trade Co., Ltd.

Tel: --
Fax: --
Email: sales@mu-intel.com
Country: China
ProdList: 217
Advantage: 38

AndaChem, Inc.

Tel: --
Fax: --
Email: sales@andachem.com
Country: China
ProdList: 3357
Advantage: 38

More

Less

View Lastest Price from 2-(2-Methylpropyl)pyridine manufacturers

Career Henan Chemical Co

Product: 2-Isobutylpyridine 6304-24-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-02-03

6304-24-1, 2-(2-Methylpropyl)pyridineRelated Search:

SERPENTINE HYDROGEN TARTRATE 3-ISOBUTYLPYRIDINE 9-AMINO-3,3-DIMETHYL-3,4-DIHYDRO-1(2H)-ACRIDINONE 2-AMINO-4-(2-CHLOROPHENYL)-6-ISOBUTYLNICOTINONITRILE 2,3-BIS[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PROPANENITRILE 2-AMINO-4-(2,3-DICHLOROPHENYL)-6-ISOBUTYLNICOTINONITRILE N-(1,10-PHENANTHROLIN-5-YL)BROMOACETAMIDE 5-(4-CHLOROPHENYL)-3-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3AH-PYRROLO[3,4-D]ISOXAZOLE-4,6(5H,6AH)-DIONE 2-AMINO-4-(4-CHLOROPHENYL)-6-ISOBUTYLNICOTINONITRILE 2-AMINO-7,7-DIMETHYL-7,8-DIHYDRO-5H-PYRANO[4,3-B]PYRIDINE-3-CARBOXYLIC ACID 2-AMINO-4-(3-CHLOROPHENYL)-6-ISOBUTYLNICOTINONITRILE DIETHYL 2-(ACETYLAMINO)-2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHYL)MALONATE AURORA KA-3427 4-(1,3-DIOXO-1,3-DIHYDRO-2H-INDEN-2-YLIDEN)-2-PHENYL-6-(2-PYRIDINYL)TETRAHYDROPYRROLO[3,4-C]PYRROLE-1,3(2H,3AH)-DIONE 2,3-DI(2-PYRIDYL)OXIRANE-2-CARBOXAMIDE SERPENTINE TARTRATE N-(1,10-PHENANTHROLIN-5-YL)IODOACETAMIDE 2,3-DI-2-PYRIDYL-2,3-BUTANEDIOL, 99%, MIXTURE OF (+/-) AND MESO

FEMA NUMBER 3370

FEMA 3370

2-ISOBUTYLPYRIDINE

2-(2-METHYLPROPYL) PYRIDINE

Pyridine, 2-(2-methylpropyl)-

6304-24-1

Organics