4-PHENOXYPHENYLHYDRAZINE HYDROCHLORIDE
- Product Name
- 4-PHENOXYPHENYLHYDRAZINE HYDROCHLORIDE
- CAS No.
- 60481-02-9
- Chemical Name
- 4-PHENOXYPHENYLHYDRAZINE HYDROCHLORIDE
- Synonyms
- N-(4-Phenoxy-phenyl)-hydrazinium;4-PHENOXYPHENYLHYDRAZINE HYDROCHLORIDE;1-(4-PHENOXYPHENYL)HYDRAZINE HYDROCHLORIDE;4-Phenoxyphenylhydrazine hydrochloride 95+%;N'-(4-PHENOXY-PHENYL)-HYDRAZINIUM, CHLORIDE
- CBNumber
- CB2456294
- Molecular Formula
- C12H13ClN2O
- Formula Weight
- 236.7
- MOL File
- 60481-02-9.mol
4-PHENOXYPHENYLHYDRAZINE HYDROCHLORIDE Property
- Melting point:
- 187-189(dec.)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- color
- Brown
- CAS DataBase Reference
- 60481-02-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, IRRITANT-HARMFUL
- HS Code
- 2928009090
N-Bromosuccinimide Price
- Product number
- JRD0815
- Product name
- 1-(4-Phenoxyphenyl)hydrazine hydrochloride
- Packaging
- 1G
- Price
- $185
- Updated
- 2025/07/31
- Product number
- P320858
- Product name
- (4-Phenoxyphenyl)hydrazineHydrochloride
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 023499
- Product name
- 4-Phenoxyphenylhydrazinehydrochloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 6539AE
- Product name
- 4-(Phenoxy)phenylhydrazinehydrochloride
- Packaging
- 250mg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- 007271
- Product name
- 4-(Phenoxy)phenylhydrazine hydrochloride
- Packaging
- 1g
- Price
- $109
- Updated
- 2021/12/16
4-PHENOXYPHENYLHYDRAZINE HYDROCHLORIDE Chemical Properties,Usage,Production
Synthesis
139-59-3
60481-02-9
The general procedure for the synthesis of 4-phenoxyphenylhydrazine hydrochloride from 4-aminodiphenyl ether is as follows: to a concentrated solution of 4-phenoxyaniline (2 g, 10.8 mmol, 1 equiv). A solution of ice-cold sodium nitrite (1.49 g, 21.6 mmol, 2.0 eq.) in water (7.6 mL) was added dropwise to hydrochloric acid (22 mL) over a period of 15 min while maintaining the reaction temperature below 10 °C. The reaction mixture was cooled to 0 °C and stirred continuously for 1 hour. Subsequently, sulfamic acid (1.05 g, 10.8 mmol, 1 eq.) was added to the reaction mixture in batches over 20 minutes. Next, a concentrated hydrochloric acid solution of tin(II) chloride dihydrate (9.78 g, 43.2 mmol, 4 eq.) was added. Hydrochloric acid (8.2 mL) was added dropwise over a period of 20 minutes while the reaction temperature was controlled to be below 15 °C. The reaction mixture was continued to be stirred at 0 °C for 2 h and then alkalized to pH 14 with 5 M aqueous sodium hydroxide solution, during which the reaction temperature was kept below 30 °C. After completion of the reaction, the reaction mixture was rapidly extracted with dichloromethane (2 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, and the solvent was removed by filtration and vacuum. The unstable (4-phenoxyphenyl) hydrazine was converted to its hydrochloride salt by using an ether (20 mL) solution of 2M hydrochloric acid. The precipitate formed was collected and dried under reduced pressure to give the final 4-phenoxyphenylhydrazine hydrochloride as a light brown solid (1.2 g, 44% yield).
References
[1] European Journal of Medicinal Chemistry, 2012, vol. 58, p. 452 - 463
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 7, p. 3152 - 3162
[3] Patent: CN105061315, 2017, B. Location in patent: Paragraph 0065; 0067
4-PHENOXYPHENYLHYDRAZINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
4-PHENOXYPHENYLHYDRAZINE HYDROCHLORIDE Suppliers
- Tel
- --
- Fax
- --
- interchim@interchim.com
- Country
- France
- ProdList
- 6302
- Advantage
- 76
View Lastest Price from 4-PHENOXYPHENYLHYDRAZINE HYDROCHLORIDE manufacturers
- Product
- 4-PHENOXYPHENYLHYDRAZINE HYDROCHLORIDE 60481-02-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- MIn98%HPLC/LC
- Supply Ability
- 100KGS
- Release date
- 2020-10-29