3-NITRO-4-CHLORO-4'-FLUOROBENZOPHENONE
- Product Name
- 3-NITRO-4-CHLORO-4'-FLUOROBENZOPHENONE
- CAS No.
- 31431-16-0
- Chemical Name
- 3-NITRO-4-CHLORO-4'-FLUOROBENZOPHENONE
- Synonyms
- Flubendazole Impurity 3;Benzophenone-4 Benzophenone-5;3-Nitro-4-Amino-4'-Fluorobenzophenone;3-Nitro-4-chloro-4'-fluorobenzophenone;4-CHLORO-3-NITRO-4'-FLUOROBENZOPHENONE;4-Chloro-3-nitrophenyl(4-fluorophenyl) ketone;(4-CHLORO-3-NITROPHENYL)(4-FLUOROPHENYL)METHANONE;Methanone,(4-chloro-3-nitrophenyl) (4-fluorophenyl)-
- CBNumber
- CB2457534
- Molecular Formula
- C13H7ClFNO3
- Formula Weight
- 279.65
- MOL File
- 31431-16-0.mol
3-NITRO-4-CHLORO-4'-FLUOROBENZOPHENONE Property
- Boiling point:
- 419.2±45.0 °C(Predicted)
- Density
- 1.430±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- color
- Yellow
- CAS DataBase Reference
- 31431-16-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C596730
- Product name
- (4-Chloro-3-nitrophenyl)(4-fluorophenyl)methanone
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- L685
- Product name
- 4-Chloro-3-nitro-4'-fluorobenzophenone
- Packaging
- 10g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FC101606
- Product name
- 4-Chloro-4'-fluoro-3-nitrobenzophenone
- Packaging
- 2g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- FC101606
- Product name
- 4-Chloro-4'-fluoro-3-nitrobenzophenone
- Packaging
- 5G
- Price
- $700
- Updated
- 2021/12/16
- Product number
- HCH0013099
- Product name
- 4-CHLORO-3-NITRO-4-FLUOROBENZOPHENONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $708.25
- Updated
- 2021/12/16
3-NITRO-4-CHLORO-4'-FLUOROBENZOPHENONE Chemical Properties,Usage,Production
Uses
(4-Chloro-3-nitrophenyl)(4-fluorophenyl)methanone (cas# 31431-16-0) is a useful chemical in the manufacturing process for flubendazole, an anthelmintic that is used in dogs and cats to treat parasites and worms.
Synthesis
462-06-6
38818-50-7
31431-16-0
To the reaction flask was added 1800 g of fluorobenzene and 2250 g of aluminum trichloride, and pre-cooled 3-nitro-4-chlorobenzoyl chloride solution was slowly added dropwise to the reaction flask, controlling the reaction temperature to be at 25-30 °C. After the dropwise addition was completed, the reaction was continued at this temperature for 2 hours. Upon completion of the reaction, the reaction mixture was slowly added dropwise to 10 kg of dilute hydrochloric acid at a concentration of 3.0%, ensuring that the temperature did not exceed 65 °C during this process. After stirring for 0.5 hours, the mixture was allowed to stand to allow the mixture to stratify, separating and retaining the lower organic phase. The organic phase was washed with 600 g of a 10% concentration aqueous sodium carbonate solution. Subsequently, the solvent o-dichlorobenzene was removed by distillation under reduced pressure, 5400 g of methanol was added to the residue and the mixture was heated to reflux. After stirring for 0.5 h, the mixture was cooled to promote crystallization. After filtration and drying, 2387 g of 4-chloro-3-nitro-4'-fluorodiphenyl ketone was obtained with a purity of 98.7% and an overall yield of 95.7%.
References
[1] Patent: CN107698516, 2018, A. Location in patent: Paragraph 0036
3-NITRO-4-CHLORO-4'-FLUOROBENZOPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-NITRO-4-CHLORO-4'-FLUOROBENZOPHENONE manufacturers
- Product
- 3-NITRO-4-CHLORO-4'-FLUOROBENZOPHENONE 31431-16-0
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-20
- Product
- 3-NITRO-4-CHLORO-4'-FLUOROBENZOPHENONE 31431-16-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-05-24