ChemicalBook > CAS DataBase List > FTBMT

FTBMT

Product Name: FTBMT
CAS No.: 1358575-02-6
Chemical Name: FTBMT
Synonyms: FTBMT;TP-024;FTBMT >=98% (HPLC);FTBMT, 10 mM in DMSO;inhibit,FTBMT,Inhibitor;4-(3-(3-Fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide;4-(3-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-5 -methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide;Benzamide, 4-[3-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methyl-
CBNumber: CB24662565
Molecular Formula: C19H16F4N4O
Formula Weight: 392.35
MOL File: 1358575-02-6.mol

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FTBMT Property

storage temp.: Store at -20°C
solubility: DMSO:69.62(Max Conc. mg/mL);177.44(Max Conc. mM)
form: Solid
color: Light yellow to orange

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 6784
Product name: FTBMT
Purity: ≥98%(HPLC)
Packaging: 25
Price: $360
Updated: 2021/12/16

TRC

Product number: F810408
Product name: FTBMT
Packaging: 2.5mg
Price: $210
Updated: 2021/12/16

AK Scientific

Product number: 8363DM
Product name: Ftbmt
Packaging: 10mg
Price: $286
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BF161243
Product name: FTBMT NEW
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Updated: 2021/12/16

AK Scientific

Product number: 8363DM
Product name: Ftbmt
Packaging: 50mg
Price: $876
Updated: 2021/12/16

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FTBMT Chemical Properties,Usage,Production

Uses

FTBMT is a GPR52 receptor agonist with an EC50 value of 71 nM. Studies demonstrate antipsychotic-like effects of FTBMT in murine models of schizophrenia. FTBMT elicits beneficial effects on cognitive processes such as spatial working memory and long-term memory in mice.

Biological Activity

FTBMT is an orally available, selective and potent agonist of GPR52. It exhibits antipsychotic and procognitive properties without causing catalepsy in rodents. FTBMT improves recognition memory in a novel object recognition test and mitigates MK-801-induced working memory deficits in a radial arm maze test in rats.

in vivo

TP-024 (FTBMT) (30 mg/kg, 90 minutes) exhibits antipsychotic-like activity without causing catalepsy in mice^[2].

TP-024 (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory in rats^[2].

TP-024 (3, 10, 30 mg/kg, 2 hours) stimulates neuronal activity in brain regions related to cognition^[2].

Animal Model:	Male Long-Evans rats (9 weeks old)^[2]
Dosage:	10 mg/kg
Administration:	Oral, 1 hour before memory test
Result:	A 1-hour pretreatment with FTBMT (10 mg/kg, p.o.) significantly decreases the number of memory errors induced by MK-801^[2].

Animal Model:	Male ICR mice (7 to 8 weeks old)^[2]
Dosage:	3–30 mg/kg
Administration:	Oral, 60 minutes before s.c. administration of MK-801
Result:	FTBMT increases phospho-DARPP32 levels in the NAc slices^[2].

storage

Store at -20°C

FTBMT Preparation Products And Raw materials

Raw materials

Preparation Products

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1358575-02-6, FTBMTRelated Search:

FTBMT

Benzamide, 4-[3-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methyl-

FTBMT >=98% (HPLC)

4-(3-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-5 -methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide

inhibit,FTBMT,Inhibitor

TP-024

4-(3-(3-Fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide

FTBMT, 10 mM in DMSO

1358575-02-6