Arylquin 1
- Product Name
- Arylquin 1
- CAS No.
- 1630743-73-5
- Chemical Name
- Arylquin 1
- Synonyms
- Arylquin 1;Arylquin 1 >=98% (HPLC);3-(2-fluorophenyl)-N7,N7-dimethyl-2,7-quinolinediamine;2,7-Quinolinediamine, 3-(2-fluorophenyl)-N7,N7-dimethyl-
- CBNumber
- CB24666048
- Molecular Formula
- C17H16FN3
- Formula Weight
- 281.33
- MOL File
- 1630743-73-5.mol
Arylquin 1 Property
- Boiling point:
- 441.4±40.0 °C(Predicted)
- Density
- 1.241±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- A crystalline solid
- pka
- 7.49±0.50(Predicted)
- color
- white to yellow to light brown
N-Bromosuccinimide Price
- Product number
- 16961
- Product name
- Arylquin 1
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 16961
- Product name
- Arylquin 1
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 16961
- Product name
- Arylquin 1
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- C3520
- Product name
- Arylquin1
- Packaging
- 10mg
- Price
- $208
- Updated
- 2021/12/16
- Product number
- 0157DY
- Product name
- Arylquin1
- Packaging
- 10mg
- Price
- $302
- Updated
- 2021/12/16
Arylquin 1 Chemical Properties,Usage,Production
Biological Activity
arylquin 1 is a potent secretagogue of the tumor suppressor protein prostate apoptosis response-4 (par-4).par-4 is ubiquitously expressed in normal cells and tissues, but it is inactivated, downregulated or mutated in several types of cancers. par-4 can selectively induce cancer cell apoptosis but not normal cells. both intracellular and secreted par-4 have a role in apoptosis induction by caspase-dependent mechanisms.
in vitro
previous study showed that arylquin 1 produced a dose-dependent secretion in mef cells and also induced robust secretion of par-4 in normal or immortalized human cells but failed to induce the secretion of par-4 in various lung tumor cells. moreover, it was found that brefeldin a, which blocked anterograde endoplasmic reticulum–golgi traffic, could inhibit basal and arylquin 1–inducible par-4 secretion, indicating that arylquin 1 regulated par-4 secretion through the classical secretory pathway. in addition, cells treated with arylquin 1 showed neither par-4 co-immunoprecipitation nor colocalization with vimentin, suggesting that arylquin 1 could displace par-4 from vimentin. this action of arylquin 1 was not associated with inhibition of vimentin expression, demonstrating that arylquin 1 might cause conformational changes in vimentin to block its ability to bind and sequester par-4 [1].
References
[1] burikhanov r et al. arylquins target vimentin to trigger par-4 secretion for tumor cell apoptosis. nat chem biol. 2014 nov;10(11):924-6.
Arylquin 1 Preparation Products And Raw materials
Raw materials
Preparation Products
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