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AD57 (hydrochloride)

Product Name
AD57 (hydrochloride)
CAS No.
2320261-72-9
Chemical Name
AD57 (hydrochloride)
Synonyms
AD57 (hydrochloride);N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea,monohydrochloride
CBNumber
CB24666215
Molecular Formula
C22H21ClF3N7O
Formula Weight
491.8966496
MOL File
2320261-72-9.mol
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AD57 (hydrochloride) Property

storage temp. 
Store at -20°C
solubility 
DMF: 14 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13975
Product name
AD57 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
13975
Product name
AD57 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
13975
Product name
AD57 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$477
Updated
2024/03/01
ApexBio Technology
Product number
C3080
Product name
AD57(hydrochloride)
Packaging
10mg
Price
$543
Updated
2021/12/16
ApexBio Technology
Product number
C3080
Product name
AD57(hydrochloride)
Packaging
5mg
Price
$307
Updated
2021/12/16
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AD57 (hydrochloride) Chemical Properties,Usage,Production

Description

Complex diseases, like cancer, may best be countered by compounds that affect multiple targets. AD57 is a polypharmacological cancer therapeutic, in that it is designed to modulate multiple targets related to cancer.1 In Drosophila, it potently inhibits the receptor tyrosine kinase RET (IC50 = 2 nM) and reduces the activity of numerous other kinases by more than 80% when given at 1 μM.1 Most notably, AD57 interferes with kinases downstream of RET, including Src, Raf, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism relevant to cancer.1

References

1. Dar, A.C., Das, T.K., Shokat, K.M., et al. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology Nature 486,80-84(2012).

AD57 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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AD57 (hydrochloride) Suppliers

China 20 United States 2 Global 22
Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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Shanghai Dongyang Biotechnology Co., Ltd.
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0512-0512-13601744364 13601744364
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chemsharker@126.com
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China
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
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China
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6828
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
Email
customer_service@efebio.com
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China
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https://hanhongsci.com/
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021-54306202 18917919676
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info@hanhongsci.com
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China
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Neobioscience Co., Ltd.
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Beijing Dongge Boye Biotechnology Co., Ltd.
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Morning Student Science and Technology (Guangzhou) Co., Ltd.
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Beijing Fubo Biotechnology Co., Ltd.
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Shanghai Yaoyun Biological Technology Co., Ltd.
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Shanghai Benrui Biotechnology Co., Ltd.
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Shanghai Hao Biological Technology Co., Ltd.
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shxiyuanbio@163.com
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Shanghai Weiwei Biological Technology Co., Ltd.
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Boao Pike
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Shanghai Jijin Chemical Technology Co., Ltd.
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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Shanghai Minmin Biotechnology Co., Ltd.
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Shenzhen Xinbosheng Biological Technology Co., Ltd.
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service@neobioscience.com
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2320261-72-9, AD57 (hydrochloride)Related Search:


  • AD57 (hydrochloride)
  • N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea,monohydrochloride
  • 2320261-72-9