PHGDH-inactive

Product Name: PHGDH-inactive
CAS No.: 1914971-16-6
Chemical Name: PHGDH-inactive
Synonyms: PHGDH-inactive;NCT-503 Inactive Control;PHGDH-inactive, 10 mM in DMSO;NCT-503 Inactive Control >=98% (HPLC);N-(4,6-dimethyl-2-pyridinyl)-4-(4-pyridinyl)-1-piperazinecarbothioamide;N-(4,6-Dimethylpyridin-2-yl)-4-(pyridin-4-yl)piperazine-1-carbothioamide;1-Piperazinecarbothioamide, N-(4,6-dimethyl-2-pyridinyl)-4-(4-pyridinyl)-;NCT-502,PHGDH-inactive,Inhibitor,control,PHGDH,PHGDH inactive,negative,PHGDHinactive,inhibit,activity
CBNumber: CB24666578
Molecular Formula: C17H21N5S
Formula Weight: 327.45
MOL File: 1914971-16-6.mol

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PHGDH-inactive Property

Boiling point:: 497.9±55.0 °C(Predicted)
Density: 1.268±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMF: 2 mg/mL; DMSO: 5 mg/mL; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/mL
form: A crystalline solid
pka: 12.96±0.20(Predicted)
color: white to beige
InChI: 1S/C17H21N5S/c1-13-11-14(2)19-16(12-13)20-17(23)22-9-7-21(8-10-22)15-3-5-18-6-4-15/h3-6,11-12H,7-10H2,1-2H3,(H,19,20,23)
InChIKey: ITLPIAAGIQAGRA-UHFFFAOYSA-N
SMILES: CC1=CC(NC(N2CCN(C3=CC=NC=C3)CC2)=S)=NC(C)=C1

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Skin Irrit. 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19717
Product name: PHGDH-inactive
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 19717
Product name: PHGDH-inactive
Purity: ≥98%
Packaging: 5mg
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 19717
Product name: PHGDH-inactive
Purity: ≥98%
Packaging: 10mg
Price: $380
Updated: 2024/03/01

Cayman Chemical

Product number: 19717
Product name: PHGDH-inactive
Purity: ≥98%
Packaging: 25mg
Price: $830
Updated: 2024/03/01

ApexBio Technology

Product number: C4845
Product name: PHGDH-inactive
Packaging: 25mg
Price: $947
Updated: 2021/12/16

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PHGDH-inactive Chemical Properties,Usage,Production

Description

PHGDH-inactive is an inactive analog of the 3-phosphoglycerate dehydrogenase (PHGDH) inhibitors NCT-502 and NCT-503. PHGDH-inactive is intended to serve as a negative control for NCT-502 and NCT-503.

Uses

PHGDH-inactive has no activity against PHGDH and serves as a negative control of NCT-502 and NCT-503[1].

References

[1] Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate [published correction appears in Nat Chem Biol. 2016 Jul 19;12 (8):656]. Nat Chem Biol. 2016;12(6):452-458. DOI:10.1038/nchembio.2070

PHGDH-inactive Preparation Products And Raw materials

Raw materials

Preparation Products

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PHGDH-inactive Suppliers

China 30 United States 3 Global 33

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1914971-16-6, PHGDH-inactiveRelated Search:

PHGDH-inactive

N-(4,6-dimethyl-2-pyridinyl)-4-(4-pyridinyl)-1-piperazinecarbothioamide

1-Piperazinecarbothioamide, N-(4,6-dimethyl-2-pyridinyl)-4-(4-pyridinyl)-

NCT-503 Inactive Control >=98% (HPLC)

NCT-502,PHGDH-inactive,Inhibitor,control,PHGDH,PHGDH inactive,negative,PHGDHinactive,inhibit,activity

N-(4,6-Dimethylpyridin-2-yl)-4-(pyridin-4-yl)piperazine-1-carbothioamide

PHGDH-inactive, 10 mM in DMSO

NCT-503 Inactive Control

1914971-16-6