Salvinorin A Propionate Property

Melting point:

217-221 °C

Boiling point:

573.4±50.0 °C(Predicted)

Density 

1.26±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Acetonitrile: 1 mg/ml; DMF: 2 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml

form 

A crystalline solid

Hazard and Precautionary Statements (GHS)

Salvinorin A Propionate Chemical Properties,Usage,Production

Description

Salvinorin A propionate is a selective partial agonist at κ₁-opioid receptors (KOR) with a K_i value of 32.6 nM. It inhibits adenylate cyclase (EC₅₀ = 4.7 nM) in HEK293 cells transfected with human KOR. It is selective for KORs over μ, δ, and ORL-1 opioid receptors and has no effect at serotonin, dopamine, muscarinic, or adrenergic receptors. In mice, salvinorin A propionate (13 μg, i.c.v.) reduces nociceptive responses in a radiant heat tail-flick assay, though not as potently as salvinorin A .