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BRD0705

Product Name
BRD0705
CAS No.
2056261-41-5
Chemical Name
BRD0705
Synonyms
BRD0705;BRD0705 ，S9638;BRD0705 (BRD-0705;BRD0705, 10 mM in DMSO;(4S)-4-ethyl-7,7-dimethyl-4-phenyl-1,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one;(S)-4-Ethyl-7,7-dimethyl-4-phenyl-4,6,7,8-tetrahydro-1H-pyrazolo[3,4-b]quinolin-5(2H)-one;5H-Pyrazolo[3,4-b]quinolin-5-one, 4-ethyl-1,2,4,6,7,8-hexahydro-7,7-dimethyl-4-phenyl-, (4S)-;β-catenin,Glycogen synthase kinase 3,leukemia,Acute,survival,BRD-0705,inhibit,Inhibitor,oral,BRD0705,myeloid,Glycogen synthase kinase-3,bioavailability,BRD 0705,GSK-3,kinase
CBNumber
CB24667681
Molecular Formula
C20H23N3O
Formula Weight
321.42
MOL File
2056261-41-5.mol
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BRD0705 Property

Boiling point:
512.0±50.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 300 mg/mL (933.36 mM)
form 
Solid
pka
14.82±0.60(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem
Product number
Axon2931
Product name
BRD0705
Purity
99%
Packaging
5mg
Price
$231
Updated
2021/12/16
ChemScene
Product number
CS-0066622
Product name
BRD0705
Purity
98.41%
Packaging
5mg
Price
$650
Updated
2021/12/16
Axon Medchem
Product number
Axon2931
Product name
BRD0705
Purity
99%
Packaging
25mg
Price
$781
Updated
2021/12/16
ChemScene
Product number
CS-0066622
Product name
BRD0705
Purity
98.41%
Packaging
10mg
Price
$1050
Updated
2021/12/16
ChemScene
Product number
CS-0066622
Product name
BRD0705
Purity
98.41%
Packaging
50mg
Price
$2950
Updated
2021/12/16
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BRD0705 Chemical Properties,Usage,Production

Description

BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor. BRD0705 can be used for acute myeloid leukemia.

Uses

BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML) research[1].

in vivo

BRD0705 (30 mg/kg; oral gavage; twice daily; NSG mice) treatment impairs leukemia initiation and prolongs survival in AML mouse models[1].

Animal Model:8-week-old male NSG mice injected with MLL-AF9 AML cells[1]
Dosage:30 mg/kg
Administration:Oral gavage; twice daily
Result:Mice survival was significantly improved.

IC 50

GSK3α: 66 nM (IC50); GSK3α: 4.8 μM (Kd); GSK-3β(WT): 515 nM (IC50)

References

[1] Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. DOI:10.1126/scitranslmed.aam8460

BRD0705 Preparation Products And Raw materials

Raw materials

Preparation Products

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BRD0705 Suppliers

China 44 United States 4 Global 48
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2990
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58

2056261-41-5, BRD0705Related Search:


  • BRD0705 (BRD-0705
  • BRD0705
  • β-catenin,Glycogen synthase kinase 3,leukemia,Acute,survival,BRD-0705,inhibit,Inhibitor,oral,BRD0705,myeloid,Glycogen synthase kinase-3,bioavailability,BRD 0705,GSK-3,kinase
  • 5H-Pyrazolo[3,4-b]quinolin-5-one, 4-ethyl-1,2,4,6,7,8-hexahydro-7,7-dimethyl-4-phenyl-, (4S)-
  • BRD0705, 10 mM in DMSO
  • BRD0705 ，S9638
  • (4S)-4-ethyl-7,7-dimethyl-4-phenyl-1,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one
  • (S)-4-Ethyl-7,7-dimethyl-4-phenyl-4,6,7,8-tetrahydro-1H-pyrazolo[3,4-b]quinolin-5(2H)-one
  • 2056261-41-5