ChemicalBook > CAS DataBase List > MK-8722

MK-8722

Product Name
MK-8722
CAS No.
1394371-71-1
Chemical Name
MK-8722
Synonyms
MK-8722;CS-2827;MK-8722 ，E1031;MK8722, 10 mM in DMSO;MK-8722;MK8722;MK 8722;1394371-71-1;AMP-activated protein kinase,MK 8722,MK8722,MK-8722,inhibit,Inhibitor,AMPK;D-Mannitol, 1,4:3,6-dianhydro-2-O-(5-[1,1'-biphenyl]-4-yl-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)-;(3S,3aS,6S,6aS)-6-((5-([1,1'-biphenyl]-4-yl)-6-chloro-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol;(3R,3aR,6R,6aR)-6-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol;(3R,3aR,6R,6aR)-6-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol , MK8722
CBNumber
CB24668198
Molecular Formula
C24H20ClN3O4
Formula Weight
449.89
MOL File
1394371-71-1.mol
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MK-8722 Property

Melting point:
215 - 219oC
Boiling point:
716.6±70.0 °C(Predicted)
Density 
1.437±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
8.22±0.40(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
InChIKey
XQMNBTZLYOOAGA-KESGOHLWNA-N
SMILES
O([C@@H]1CO[C@]2([H])[C@H](O)CO[C@]12[H])C1NC2=CC(Cl)=C(C3C=CC(C4C=CC=CC=4)=CC=3)N=C2N=1 |&1:1,4,6,10,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M424840
Product name
MK8722
Packaging
1mg
Price
$85
Updated
2021/12/16
TRC
Product number
M424840
Product name
MK8722
Packaging
2.5mg
Price
$185
Updated
2021/12/16
ChemScene
Product number
CS-0039843
Product name
MK8722
Purity
98.87%
Packaging
5mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0039843
Product name
MK8722
Purity
98.87%
Packaging
10mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0039843
Product name
MK8722
Purity
98.87%
Packaging
50mg
Price
$1200
Updated
2021/12/16
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MK-8722 Chemical Properties,Usage,Production

Uses

MK8722 is a systemic, direct pan-activator of AMP-activated protein kinase.

in vivo

Chronic antihyperglycemic efficacy of MK8722 (MK-8722) is evaluated in db/db mice, a leptin receptor-deficient T2DM model. Once-daily administration of MK8722 results in dose-dependent lowering of ambient blood glucose. On treatment day 12, glucose reductions after MK8722 treatment (30 mpk/day) are comparable to those observed with the PPARγ agonist BRL49653 (3 mpk/day). Unlike BRL49653, the glucose-lowering action of MK8722 manifests without significant effects on body weight, which is a consistent finding. Dose-dependent increases in tissue pACC are maintained throughout the dosing period. Chronic efficacy, without tachyphylaxis, is also observed in additional dysmetabolic and diabetic rodent models. In all cases, efficacy is associated with trough MK8722 plasma levels comparable to the concentrations required to acutely stimulate skeletal muscle glucose uptake. Chronic MK8722 dosing in mice also increases muscle Glut4 protein levels, possibly contributing to efficacy[1].

IC 50

AMPK

MK-8722 Preparation Products And Raw materials

Raw materials

Preparation Products

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1394371-71-1, MK-8722Related Search:


  • CS-2827
  • (3S,3aS,6S,6aS)-6-((5-([1,1'-biphenyl]-4-yl)-6-chloro-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol
  • MK-8722;MK8722;MK 8722;1394371-71-1
  • MK-8722
  • D-Mannitol, 1,4:3,6-dianhydro-2-O-(5-[1,1'-biphenyl]-4-yl-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)-
  • AMP-activated protein kinase,MK 8722,MK8722,MK-8722,inhibit,Inhibitor,AMPK
  • (3R,3aR,6R,6aR)-6-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol
  • (3R,3aR,6R,6aR)-6-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol , MK8722
  • MK8722, 10 mM in DMSO
  • MK-8722 ，E1031
  • 1394371-71-1