PBD-150

Product Name: PBD-150
CAS No.: 790663-33-1
Chemical Name: PBD-150
Synonyms: PBD-150;PBD-150 ，S0529;PBD-150, 10 mM in DMSO;1-(3-(1H-imidazol-1-yl)propyl)-3-(3,4-dimethoxyphenyl)thiourea;Thiourea, N-(3,4-dimethoxyphenyl)-N'-[3-(1H-imidazol-1-yl)propyl]-;Inhibitor,Amyloid-β,PBD150,Abeta,PBD-150,β-amyloid peptide,inhibit,PBD 150,Alzheimer
CBNumber: CB24668330
Molecular Formula: C15H20N4O2S
Formula Weight: 320.41
MOL File: 790663-33-1.mol

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PBD-150 Property

Melting point:: 160.0-161.0 °C(Solv: ethanol (64-17-5))
Boiling point:: 502.7±60.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml)
form: solid
pka: 12.29±0.70(Predicted)
color: White
Stability:: Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0069369
Product name: PBD-150
Purity: 98.00%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0069369
Product name: PBD-150
Purity: 98.00%
Packaging: 10mg
Price: $275
Updated: 2021/12/16

ChemScene

Product number: CS-0069369
Product name: PBD-150
Purity: 98.00%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

DC Chemicals

Product number: DC11797
Product name: PBD-150
Purity: >98%
Packaging: 100mg
Price: $550
Updated: 2021/12/16

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PBD-150 Chemical Properties,Usage,Production

Description

PBD-150 (790663-33-1) is an inhibitor of human glutaminyl cyclase (IC50 = 60 nM).1 PBD-150 diminished Ab plaque formation and gliosis while improving memory in a mouse model with small amounts of Ab3(pE)-40/42.2

Uses

PBD-150 is a human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor, with a Ki value of 490 nM[1][2].

in vivo

PBD-150 is able to reduce the deposition of pyroglutamate-modified amyloid-β peptides in brain of transgenic mouse models of Alzheimer disease, leading to a significant improvement of learning and memory in those transgenic animals^[3].

References

[1] MIRKO BUCHHOLZ. The First Potent Inhibitors for Human Glutaminyl Cyclase: Synthesis and Structure−Activity Relationship[J]. Journal of Medicinal Chemistry, 2005, 49 2: 664-677. DOI:10.1021/jm050756e
[2] STEPHAN SCHILLING. Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer”s disease–like pathology[J]. Nature Medicine, 2008, 14 10: 1106-1111. DOI:10.1038/nm.1872

PBD-150 Preparation Products And Raw materials

Raw materials

Preparation Products

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PBD-150 Suppliers

China 31 United States 5 Global 36

ChemShuttle, Inc.

Tel: 0510-83588313-811 18800520310
Email: sales@chemshuttle.com
Country: China
ProdList: 2999
Advantage: 62

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 9695
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
Advantage: 62

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
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cjbscvictory

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Jinan Jiuli Biotechnology Co. , Ltd.

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Country: China
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Hefei Mokai Pharmaceutical Technology Co., Ltd

Tel: 18130062233
Email: 690231469@qq.com
Country: China
ProdList: 8100
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790663-33-1, PBD-150Related Search:

Levetiracetam Dequalinium chloride BI 2536 Ibrutinib

PBD-150

1-(3-(1H-imidazol-1-yl)propyl)-3-(3,4-dimethoxyphenyl)thiourea

Inhibitor,Amyloid-β,PBD150,Abeta,PBD-150,β-amyloid peptide,inhibit,PBD 150,Alzheimer

Thiourea, N-(3,4-dimethoxyphenyl)-N'-[3-(1H-imidazol-1-yl)propyl]-

PBD-150, 10 mM in DMSO

PBD-150 ，S0529

790663-33-1