ChemicalBook > CAS DataBase List > RV521

RV521

Product Name: RV521
CAS No.: 1903763-82-5
Chemical Name: RV521
Synonyms: RV521;Sisunatovir;RV521 free base;Sisunatovir/RV521;Sisunatovir (Synonyms: RV521);1'-((5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one;1'-((5-(Aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one;Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzimidazol-2-yl]methyl]-6'-fluoro-;1'-{[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-1,3-benzodiazol-2-yl]methyl}-6'-fluoro-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-2'-one
CBNumber: CB24668471
Molecular Formula: C23H22F4N4O
Formula Weight: 446.44
MOL File: 1903763-82-5.mol

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RV521 Property

Boiling point:: 651.9±55.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 3.33 mg/mL (7.46 mM; Need ultrasonic)
pka: 8.75±0.50(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C23H22F4N4O/c24-15-3-4-16-19(11-15)31(21(32)22(16)7-8-22)13-20-29-17-10-14(12-28)2-5-18(17)30(20)9-1-6-23(25,26)27/h2-5,10-11H,1,6-9,12-13,28H2
InChIKey: JOPCJJSYRPUEDS-UHFFFAOYSA-N
SMILES: C12(C3=C(N(CC4N(CCCC(F)(F)F)C5=CC=C(CN)C=C5N=4)C1=O)C=C(F)C=C3)CC2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0082715
Product name: Sisunatovir
Purity: 99.08%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0082715
Product name: Sisunatovir
Purity: 99.08%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0082715
Product name: Sisunatovir
Purity: 99.08%
Packaging: 25mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0082715
Product name: Sisunatovir
Purity: 99.08%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0082715
Product name: Sisunatovir
Purity: 99.08%
Packaging: 100mg
Price: $1150
Updated: 2021/12/16

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RV521 Chemical Properties,Usage,Production

Uses

Sisunatovir (RV521) is a potent and orally active respiratory syncytial virus (RSV) inhibitor with IC50 values of 1.4, 1.0 nM for RSV A, RSV B, respectively. Sisunatovir inhibits RSV infection and reduces virus titers in the lungs of mice[1].

in vivo

Sisunatovir (0, 1, 10, 50 mg/kg; p.o.) reduces virus titers in the lungs of mice with RSV A2 infection^[1].

References

[1] DeVincenzo J, et al. A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein. Antimicrob Agents Chemother. 2020;64(2):e01884-19. Published 2020 Jan 27. DOI:10.1128/AAC.01884-19

RV521 Preparation Products And Raw materials

Raw materials

Preparation Products

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1903763-82-5, RV521Related Search:

RV521

Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzimidazol-2-yl]methyl]-6'-fluoro-

Sisunatovir (Synonyms: RV521)

Sisunatovir

RV521 free base

1'-{[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-1,3-benzodiazol-2-yl]methyl}-6'-fluoro-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-2'-one

1'-((5-(Aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one

1'-((5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one

Sisunatovir/RV521

1903763-82-5