T-025

Product Name: T-025
CAS No.: 2407433-00-3
Chemical Name: T-025
Synonyms: T-025;T025,T-025;T025, 10 mM in DMSO;N2-Methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine;7H-Pyrrolo[2,3-d]pyrimidine-2,4-diamine, N2-methyl-N4-(2-pyrimidinylmethyl)-5-(6-quinolinyl)-;N2-Methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine , T025
CBNumber: CB24668567
Molecular Formula: C21H18N8
Formula Weight: 382.42
MOL File: 2407433-00-3.mol

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T-025 Property

Density: 1.432±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 8.25 mg/mL (21.57 mM; Need ultrasonic)
pka: 13.45±0.50(Predicted)
form: Solid
color: Yellow to green

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0044754
Product name: T025
Purity: 98.61%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

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T-025 Chemical Properties,Usage,Production

Biological Activity

T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with Kd values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively. T025 induces caspase-3/7-mediated cell apoptosis. T025 reduces CLK-dependent phosphorylation. T025 exerts anti-proliferative activities in both hematological and solid cancer cell lines (IC50 values: 30-300 nM). T025 has an anti-tumor efficiency, mainly for MYC-driven disease research[1]. T025 (0-1000 nM; 72 hours) significantly suppresses the growth of MDA-MB-468 cells in a dose-dependent manner[1].T025 (0-1000 nM; 6 hours) reduces phosphorylation levels in MDA-MB-468 cells[1]. T025 (50 mg/kg; p.o.; 2, 4, 8 hours, Balb/c nude mice (7 to 8 week-old females).) suppress the CLK-dependent phosphorylation and induce skipping exon in various genes[1]. T025 (50 mg/kg; p.o.; twice daily on 2 days per week, for 3 weeks, Balb/c nude mice (7 to 8 week-old females).) inhibits MDA-MB-468 xenograft mice tumor growth and without affect body weight [1].

References

[1]. Iwai K, et al. Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability. EMBO Mol Med. 2018 Jun;10(6):e8289.

T-025 Preparation Products And Raw materials

Raw materials

Preparation Products

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T-025 Suppliers

China 22 United States 3 Global 25

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2407433-00-3, T-025Related Search:

T-025

T025,T-025

7H-Pyrrolo[2,3-d]pyrimidine-2,4-diamine, N2-methyl-N4-(2-pyrimidinylmethyl)-5-(6-quinolinyl)-

N2-Methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

N2-Methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine , T025

T025, 10 mM in DMSO

2407433-00-3