T-3775440 hydrochloride

Product Name: T-3775440 hydrochloride
CAS No.: 1422535-52-1
Chemical Name: T-3775440 hydrochloride
Synonyms: T-3775440HCl;T 3775440;T3775440;T-3775440 hydrochloride;T-3775440 hydrochloride, 10 mM in DMSO;N-(4-(trans-2-((Cyclopropylmethyl)amino)cyclopropyl)phenyl)-1-methyl-1H-pyrazole-4-carboxamide hydrochloride;T3775440 hydrochloride,T-3775440,inhibit,T3775440,T 3775440,Inhibitor,T 3775440 hydrochloride,Histone Demethylase
CBNumber: CB24668572
Molecular Formula: C18H23ClN4O
Formula Weight: 346.86
MOL File: 1422535-52-1.mol

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T-3775440 hydrochloride Property

storage temp.: Store at -20°C
solubility: DMSO : ≥ 30.18 mg/mL (87.01 mM)
form: Solid
color: Light yellow to yellow
InChI: InChI=1/C18H22N4O.ClH/c1-22-11-14(10-20-22)18(23)21-15-6-4-13(5-7-15)16-8-17(16)19-9-12-2-3-12;/h4-7,10-12,16-17,19H,2-3,8-9H2,1H3,(H,21,23);1H/t16-,17+;/s3
InChIKey: XYFPAGOQZFSLFH-NAHYZYKJNA-N
SMILES: N([C@@H]1C[C@H]1C1C=CC(NC(C2C=NN(C)C=2)=O)=CC=1)CC1CC1.Cl |&1:1,3,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: BT168491
Product name: T 3775440 hydrochloride
Packaging: 5mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0023825
Product name: T-3775440hydrochloride
Purity: 99.13%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

AK Scientific

Product number: 7208EA
Product name: T-3775440Hydrochloride
Packaging: 5mg
Price: $455
Updated: 2021/12/16

ChemScene

Product number: CS-0023825
Product name: T-3775440hydrochloride
Purity: 99.13%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BT168491
Product name: T 3775440 hydrochloride
Packaging: 25mg
Price: $905
Updated: 2021/12/16

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T-3775440 hydrochloride Chemical Properties,Usage,Production

Uses

T-3775440 (hydrochloride) is an irreversible lysine-specific histone demethylase (LSD1) inhibitor with an IC50 value of 2.1 nM.

Biological Activity

Target	Value
LSD1 ()	2.1 nM

Biological Activity

T-3775440 hydrochloride is an irreversible LSD1 inhibitor. It is highly selective for LSD1 relative to other monoamine oxidases with IC50 of 2.1 nM.

in vitro

T-3775440 hydrochloride enhances the transdifferentiation of erythrocytes/megakaryocytes to granule-like monocytes. It disrupts the interaction of LSD1 and GFI1B. AEL (TF-1a, HEL92.1.7) cells and AMKL (CMK11-5, M07e) cells were treated with T-3775440 for 48 hours, which induced cell cycle arrest and apoptosis. In TF-1a and CMK11-5 cells, treatment with T-3775440 increased cells in G1 and sub-G1 phases.

in vivo

T-3775440 inhibits tumor growth in a mouse xenograft model of AML. In mice T-3775440 hydrochloride caused a transient decrease in platelets followed by a large rebound. After a single dose, it had no apparent effect on red blood cell counts. T-3775440 hydrochloride also exerted antitumor activity in AEL (HEL 92.1.7) model and AMKL (CMK11-5) model.

IC 50

KDM1/LSD1

References

[1] Ishikawa Y, et al. A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells. Mol Cancer Ther. 2017 Feb;16(2):273-284. DOI:10.1158/1535-7163.MCT-16-0471

T-3775440 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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T-3775440 hydrochloride Suppliers

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T-3775440 hydrochloride, 10 mM in DMSO

N-(4-(trans-2-((Cyclopropylmethyl)amino)cyclopropyl)phenyl)-1-methyl-1H-pyrazole-4-carboxamide hydrochloride

1422535-52-1