T-3775440 hydrochloride

Product Name: T-3775440 hydrochloride
CAS No.: 1422535-52-1
Chemical Name: T-3775440 hydrochloride
Synonyms: T-3775440HCl;T 3775440;T3775440;T-3775440 hydrochloride;T-3775440 hydrochloride, 10 mM in DMSO;N-(4-(trans-2-((Cyclopropylmethyl)amino)cyclopropyl)phenyl)-1-methyl-1H-pyrazole-4-carboxamide hydrochloride;T3775440 hydrochloride,T-3775440,inhibit,T3775440,T 3775440,Inhibitor,T 3775440 hydrochloride,Histone Demethylase
CBNumber: CB24668572
Molecular Formula: C18H23ClN4O
Formula Weight: 346.86
MOL File: 1422535-52-1.mol

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T-3775440 hydrochloride Property

storage temp.: Store at -20°C
solubility: DMSO : ≥ 30.18 mg/mL (87.01 mM)
form: Solid
color: Light yellow to yellow
InChI: InChI=1/C18H22N4O.ClH/c1-22-11-14(10-20-22)18(23)21-15-6-4-13(5-7-15)16-8-17(16)19-9-12-2-3-12;/h4-7,10-12,16-17,19H,2-3,8-9H2,1H3,(H,21,23);1H/t16-,17+;/s3
InChIKey: XYFPAGOQZFSLFH-NAHYZYKJNA-N
SMILES: N([C@@H]1C[C@H]1C1C=CC(NC(C2C=NN(C)C=2)=O)=CC=1)CC1CC1.Cl |&1:1,3,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: BT168491
Product name: T 3775440 hydrochloride
Packaging: 5mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0023825
Product name: T-3775440hydrochloride
Purity: 99.13%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

AK Scientific

Product number: 7208EA
Product name: T-3775440Hydrochloride
Packaging: 5mg
Price: $455
Updated: 2021/12/16

ChemScene

Product number: CS-0023825
Product name: T-3775440hydrochloride
Purity: 99.13%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BT168491
Product name: T 3775440 hydrochloride
Packaging: 25mg
Price: $905
Updated: 2021/12/16

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T-3775440 hydrochloride Chemical Properties,Usage,Production

Uses

T-3775440 (hydrochloride) is an irreversible lysine-specific histone demethylase (LSD1) inhibitor with an IC50 value of 2.1 nM.

Biological Activity

Target	Value
LSD1 ()	2.1 nM

Biological Activity

T-3775440 hydrochloride is an irreversible LSD1 inhibitor. It is highly selective for LSD1 relative to other monoamine oxidases with IC50 of 2.1 nM.

in vitro

T-3775440 hydrochloride enhances the transdifferentiation of erythrocytes/megakaryocytes to granule-like monocytes. It disrupts the interaction of LSD1 and GFI1B. AEL (TF-1a, HEL92.1.7) cells and AMKL (CMK11-5, M07e) cells were treated with T-3775440 for 48 hours, which induced cell cycle arrest and apoptosis. In TF-1a and CMK11-5 cells, treatment with T-3775440 increased cells in G1 and sub-G1 phases.

in vivo

T-3775440 inhibits tumor growth in a mouse xenograft model of AML. In mice T-3775440 hydrochloride caused a transient decrease in platelets followed by a large rebound. After a single dose, it had no apparent effect on red blood cell counts. T-3775440 hydrochloride also exerted antitumor activity in AEL (HEL 92.1.7) model and AMKL (CMK11-5) model.

IC 50

KDM1/LSD1

References

[1] Ishikawa Y, et al. A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells. Mol Cancer Ther. 2017 Feb;16(2):273-284. DOI:10.1158/1535-7163.MCT-16-0471

T-3775440 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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T-3775440 hydrochloride Suppliers

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1422535-52-1, T-3775440 hydrochlorideRelated Search:

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T3775440 hydrochloride,T-3775440,inhibit,T3775440,T 3775440,Inhibitor,T 3775440 hydrochloride,Histone Demethylase

T-3775440 hydrochloride, 10 mM in DMSO

N-(4-(trans-2-((Cyclopropylmethyl)amino)cyclopropyl)phenyl)-1-methyl-1H-pyrazole-4-carboxamide hydrochloride

1422535-52-1