ChemicalBook > CAS DataBase List > T-3775440 hydrochloride

T-3775440 hydrochloride

Product Name
T-3775440 hydrochloride
CAS No.
1422535-52-1
Chemical Name
T-3775440 hydrochloride
Synonyms
T-3775440HCl;T 3775440;T3775440;T-3775440 hydrochloride;T3775440 hydrochloride,T-3775440,inhibit,T3775440,T 3775440,Inhibitor,T 3775440 hydrochloride,Histone Demethylase
CBNumber
CB24668572
Molecular Formula
C18H23ClN4O
Formula Weight
346.86
MOL File
1422535-52-1.mol
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T-3775440 hydrochloride Property

storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 30.18 mg/mL (87.01 mM)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
BT168491
Product name
T 3775440 hydrochloride
Packaging
5mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0023825
Product name
T-3775440hydrochloride
Purity
99.13%
Packaging
5mg
Price
$450
Updated
2021/12/16
AK Scientific
Product number
7208EA
Product name
T-3775440Hydrochloride
Packaging
5mg
Price
$455
Updated
2021/12/16
ChemScene
Product number
CS-0023825
Product name
T-3775440hydrochloride
Purity
99.13%
Packaging
10mg
Price
$750
Updated
2021/12/16
Biosynth Carbosynth
Product number
BT168491
Product name
T 3775440 hydrochloride
Packaging
25mg
Price
$905
Updated
2021/12/16
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T-3775440 hydrochloride Chemical Properties,Usage,Production

Biological Activity

TargetValue
LSD1
()
2.1 nM

Biological Activity

T-3775440 hydrochloride is an irreversible LSD1 inhibitor. It is highly selective for LSD1 relative to other monoamine oxidases with IC50 of 2.1 nM.

in vitro

T-3775440 hydrochloride enhances the transdifferentiation of erythrocytes/megakaryocytes to granule-like monocytes. It disrupts the interaction of LSD1 and GFI1B. AEL (TF-1a, HEL92.1.7) cells and AMKL (CMK11-5, M07e) cells were treated with T-3775440 for 48 hours, which induced cell cycle arrest and apoptosis. In TF-1a and CMK11-5 cells, treatment with T-3775440 increased cells in G1 and sub-G1 phases.

in vivo

T-3775440 inhibits tumor growth in a mouse xenograft model of AML. In mice T-3775440 hydrochloride caused a transient decrease in platelets followed by a large rebound. After a single dose, it had no apparent effect on red blood cell counts. T-3775440 hydrochloride also exerted antitumor activity in AEL (HEL 92.1.7) model and AMKL (CMK11-5) model.

T-3775440 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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T-3775440 hydrochloride Suppliers

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1422535-52-1, T-3775440 hydrochlorideRelated Search:


  • T-3775440HCl
  • T-3775440 hydrochloride
  • T 3775440;T3775440
  • T3775440 hydrochloride,T-3775440,inhibit,T3775440,T 3775440,Inhibitor,T 3775440 hydrochloride,Histone Demethylase
  • 1422535-52-1