BI-409306

Product Name: BI-409306
CAS No.: 1189767-28-9
Chemical Name: BI-409306
Synonyms: CS-2883;BI-409306;Osoresnontrine;BI-409306 ，S0039;BI 409306 (BI-409306;BI-409306 (Osoresnontrine);BI 409306;BI-409306;BI409306;Osoresnontrine, 10 mM in DMSO;Osoresnontrine,Inhibitor,BI409306,Phosphodiesterase (PDE),inhibit,BI 409306;6-(pyridin-2-ylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
CBNumber: CB24668895
Molecular Formula: C16H17N5O2
Formula Weight: 311.34
MOL File: 1189767-28-9.mol

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BI-409306 Property

Boiling point:: 559.8±60.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:62.0(Max Conc. mg/mL);199.14(Max Conc. mM)
form: A crystalline solid
pka: 3.94±0.12(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30375
Product name: BI-409306
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 30375
Product name: BI-409306
Packaging: 25mg
Price: $745
Updated: 2024/03/01

Cayman Chemical

Product number: 30375
Product name: BI-409306
Packaging: 5mg
Price: $194
Updated: 2024/03/01

Cayman Chemical

Product number: 30375
Product name: BI-409306
Packaging: 10mg
Price: $330
Updated: 2024/03/01

AK Scientific

Product number: 6416EM
Product name: 1-(Oxan-4-yl)-6-(pyridin-2-ylmethyl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
Packaging: 5mg
Price: $314
Updated: 2021/12/16

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BI-409306 Chemical Properties,Usage,Production

Uses

Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders.

IC 50

PDE9A: 52 nM (IC₅₀); PDE1C: 1 μM (IC₅₀); PDE1A: 1.4 μM (IC₅₀)

References

[1] Cornelia Dorner-Ciossek, et al. BI 409306, a novel phosphodiesterase 9A inhibitor, part I: potency, selectivity and in-vitro functional characterization on synaptic plasticity. International Congress on Schizophrenia Research.

BI-409306 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI-409306 Suppliers

China 50 United States 8 Global 58

BOC Sciences

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1189767-28-9, BI-409306Related Search:

BI-409306

BI 409306 (BI-409306

CS-2883

BI 409306;BI-409306;BI409306

6-(pyridin-2-ylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-6-(2-pyridinylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-

6-(Pyridin-2-ylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

Osoresnontrine

Osoresnontrine,Inhibitor,BI409306,Phosphodiesterase (PDE),inhibit,BI 409306

BI-409306 (Osoresnontrine)

Osoresnontrine, 10 mM in DMSO

BI-409306 ，S0039

1189767-28-9

118967-28-9