ChemicalBook > CAS DataBase List > TVB-3166

TVB-3166

Product Name: TVB-3166
CAS No.: 1533438-83-3
Chemical Name: TVB-3166
Synonyms: TVB-3166;TVB-3166 ，S3576;TVB-3166,TVB3166;TVB-3166 >=98% (HPLC);TVB-3166, 10 mM in DMSO;TVB 3166,inhibit,TVB3166,Apoptosis,TVB-3166,Inhibitor,Fatty Acid Synthase (FASN);4-(1-(5-(4,5-Dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrile;Benzonitrile, 4-[1-[5-(4,5-dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl]-3-azetidinyl]-
CBNumber: CB24670650
Molecular Formula: C24H24N4O
Formula Weight: 384.47
MOL File: 1533438-83-3.mol

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TVB-3166 Property

Boiling point:: 641.5±55.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO:5.0(Max Conc. mg/mL);13.0(Max Conc. mM)
form: powder
pka: 14.66±0.50(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1694
Product name: TVB-3166
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $138
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1694
Product name: TVB-3166
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $558
Updated: 2025/07/31

ChemScene

Product number: CS-0077865
Product name: TVB-3166
Purity: 99.55%
Packaging: 50mg
Price: $590
Updated: 2021/12/16

ChemScene

Product number: CS-0077865
Product name: TVB-3166
Purity: 99.55%
Packaging: 100mg
Price: $990
Updated: 2021/12/16

ChemScene

Product number: CS-0077865
Product name: TVB-3166
Purity: 99.55%
Packaging: 10mg
Price: $170
Updated: 2021/12/16

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TVB-3166 Chemical Properties,Usage,Production

Uses

TVB-3166 is an orally-available, reversible, and selective fatty acid synthase (FASN) inhibitor with IC50s of 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis, respectively. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor growth[1].

Biochem/physiol Actions

TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p.o.), while exhibiting little or no anti-proliferation activity toward non-palmitate-dependent growth of cancer and non-cancer cultures. FASN inhibition by TVB-3166 treatment is also effective against the replications respiratory viruses both in cultures (Effc. conc. 200 nM against RSV and PIV3 in A549, HEp2, and HeLa cultures) and in mice (50 mg/kg/12 h, p.o.; RSV) in vivo without significant adverse effects to the host cells or mice.

in vivo

TVB-3166 (Oral gavage; 30-100 mg/kg/day) inhibits xenograft tumor growth^[1].
TVB-3166 (Oral gavage; 30-100 mg/kg/day) has the concentration is approximately 3-fold higher in plasma than tumor. The 100 and 30 mg/kg groups had plasma and tumor concentrations of 7 and 2.9 μM, respectively^[1].

Animal Model:	Female BALB-c-nude mice^[1]
Dosage:	30, 60, or 100 mg/kg
Administration:	Oral gavage; once daily
Result:	Inhibited xenograft tumor growth.

Animal Model:	Female BALB-c-nude mice^[1]
Dosage:	30, 60, or 100 mg/kg (Pharmacokinetic Study)
Administration:	Oral gavage; once daily
Result:	The concentration was approximately 3-fold higher in plasma than tumor. The 100 and 30 mg/kg groups had plasma and tumor concentrations of 7 and 2.9 μM, respectively.

References

[1] Ventura R, et al. Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression. EBioMedicine. 2015 Jul 2;2(8):808-24. DOI:10.1016/j.ebiom.2015.06.020

TVB-3166 Preparation Products And Raw materials

Raw materials

Preparation Products

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1533438-83-3, TVB-3166Related Search:

TVB-3166

TVB-3166,TVB3166

Benzonitrile, 4-[1-[5-(4,5-dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl]-3-azetidinyl]-

TVB-3166 >=98% (HPLC)

4-(1-(5-(4,5-Dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrile

TVB 3166,inhibit,TVB3166,Apoptosis,TVB-3166,Inhibitor,Fatty Acid Synthase (FASN)

TVB-3166, 10 mM in DMSO

TVB-3166 ，S3576

1533438-83-3