CPI-455 Hydrochloride

Product Name: CPI-455 Hydrochloride
CAS No.: 2095432-28-1
Chemical Name: CPI-455 Hydrochloride
Synonyms: CPI-455 Hydrochloride;CPI455 HCl,CPI 455 HCl;6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride
CBNumber: CB24672063
Molecular Formula: C16H15ClN4O
Formula Weight: 314.77
MOL File: 2095432-28-1.mol

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CPI-455 Hydrochloride Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: ≥31.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
Water Solubility: Water: Insoluble

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth

Product number: VID43228
Product name: CPI-455 HCl
Packaging: 25mg
Price: $982.75
Updated: 2026/06/05

Biosynth

Product number: VID43228
Product name: CPI-455 HCl
Packaging: 50mg
Price: $1367.5
Updated: 2026/06/05

Biosynth

Product number: VID43228
Product name: CPI-455 HCl
Packaging: 100mg
Price: $2188
Updated: 2026/06/05

ChemScene

Product number: CS-0101986
Product name: CPI-455 hydrochloride
Purity: 99.95%
Packaging: 1mg
Price: $48
Updated: 2026/06/04

ChemScene

Product number: CS-0101986
Product name: CPI-455 hydrochloride
Purity: 99.95%
Packaging: 5mg
Price: $96
Updated: 2026/06/04

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CPI-455 Hydrochloride Chemical Properties,Usage,Production

Uses

CPI-455 hydrochloride is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 hydrochloride mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents[1].

Biological Activity

cpi-455 is a kdm5 inhibitor.the kdm5 family of histone demethylases catalyzes the demethylation of histone h3 on lysine 4 (h3k4) and is required for the survival of drug-tolerant persister cancer cells (dtps).

in vitro

previous study found that cpi-455 could potently inhibit the fulllength kdm5a in enzymatic assays with a half-maximal inhibitory concentration of 10 ± 1 nm. cpi-455 inhibited kdm5a, kdm5b and kdm5c to similar levels but showed significantly weaker potency toward kdm4c and kdm7b (~200- and 770-fold, respectively) and no detectable inhibition of kdm2b, kdm3b or kdm6a. moreover, it was found that the cpi-455-mediated kdm5 inhibition led to a dose-dependent increase in global h3k4me3 in hela cells, and the removal of cpi-455 resulted in a rapid reversal of h3k4me3 increases in hela cells. moreover, cpi-455 could delay the appearance of heavy h3k4me3, which was consistent with the role for kdm5 enzymes in h3k4me3 turnover, however, the turnover of h3k4me2 was only marginally altered. as expected, cpi-455 could affect the turnover of h3k4 monomethylation [1].

in vivo

Dual blockade of B7-H4 and KDM5B (CPI-455 hydrochloride, 50/70 mg/kg, ip, daily) in mice elicits protective immunity^[2].

target

Target	Value
KDM5A (Cell-free assay)	10 nM

IC 50

10 nm

References

[1] vinogradova m, et al. an inhibitor of kdm5 demethylases reduces survival of drug-tolerant cancer cells. nat chem biol. 2016 jul;12(7):531-8.

CPI-455 Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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CPI-455 Hydrochloride Suppliers

China 25 India 1 United States 4 Global 30

Sichuan Wei Keqi Biological Technology Co., Ltd.

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2095432-28-1, CPI-455 HydrochlorideRelated Search:

CPI-455 Hydrochloride

6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride

CPI455 HCl,CPI 455 HCl

2095432-28-1