ChemicalBook > CAS DataBase List > GC 14
GC 14
- Product Name
- GC 14
- CAS No.
- 447415-34-1
- Chemical Name
- GC 14
- Synonyms
- GC 14;Acetic acid, 2-[4-[[6-hydroxy-5-(1-methylethyl)-4'-nitro[1,1'-biphenyl]-3-yl]methyl]-3,5-dimethylphenoxy]-
- CBNumber
- CB24672634
- Molecular Formula
- C26H27NO6
- Formula Weight
- 449.5
- MOL File
- 447415-34-1.mol
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GC 14 Property
- Boiling point:
- 632.4±55.0 °C(Predicted)
- Density
- 1.241±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 3.15±0.10(Predicted)
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GC 14 Chemical Properties,Usage,Production
Description
GC 14 is a thyroid hormone antagonist.
GC 14 contains extensions at the 5′-position of the outer thyronine ring or from the bridging carbon and has only a modest affinity and potency for the thyroid hormone receptor (TR) that limits studies of their antagonistic actions[2].
References
[1]. Chiellini G, et al. Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives. Bioorg Med Chem. 2002 Feb;10(2):333-46. [2]. Nguyen NH, et al. Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem. 2002 Jul 18;45(15):3310-20.
GC 14 Preparation Products And Raw materials
Raw materials
Preparation Products
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