1H-PYRAZOLE-3-CARBONITRILE, 4-AMINO-
- Product Name
- 1H-PYRAZOLE-3-CARBONITRILE, 4-AMINO-
- CAS No.
- 68703-67-3
- Chemical Name
- 1H-PYRAZOLE-3-CARBONITRILE, 4-AMINO-
- Synonyms
- 4-AMINO-1H-PYRAZOLE-3-CARBONITRILE;4-AMINO-1H-PYRAZOLE-5-CARBONITRILE;1H-PYRAZOLE-3-CARBONITRILE, 4-AMINO-;1H-Pyrazole-3-carbonitrile,4-amino-(9CI)
- CBNumber
- CB2468347
- Molecular Formula
- C4H4N4
- Formula Weight
- 108.1
- MOL File
- 68703-67-3.mol
1H-PYRAZOLE-3-CARBONITRILE, 4-AMINO- Property
- Melting point:
- 143.5-145.0 °C
- Boiling point:
- 476.4±30.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 13.22±0.50(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- A636068
- Product name
- 4-Amino-1H-pyrazole-3-carbonitrile
- Packaging
- 50mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CHM0311679
- Product name
- 4-AMINO-1H-PYRAZOLE-3-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.84
- Updated
- 2021/12/16
- Product number
- 61-10288
- Product name
- 4-Amino-1H-pyrazole-3-carbonitrile
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $585
- Updated
- 2021/12/16
- Product number
- CM120436
- Product name
- 4-Aminopyrazole-5-carbonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $713
- Updated
- 2021/12/16
- Product number
- CM120436
- Product name
- 4-Aminopyrazole-5-carbonitrile
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
1H-PYRAZOLE-3-CARBONITRILE, 4-AMINO- Chemical Properties,Usage,Production
Synthesis
61241-07-4
68703-67-3
The general procedure for the synthesis of 4-amino-1H-pyrazole-3-carbonitrile from 4-nitro-1H-pyrazole-3-carbonitrile was as follows: 4-nitro-1H-pyrazole-3-carbonitrile (7.24 mmol) was dissolved in methanol (200 mL), 10% Pd/C catalyst was added (catalyst dosage of 10% of the mass of the raw material w/w), and hydrogenation was carried out in the Parr hydrogenation unit at 30 psi hydrogen pressure for 24 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give a dark brown solid product. The product was pure enough to be used directly in the subsequent reaction in 90% yield. The structure of the product was confirmed by 1H NMR (DMSO-d6): δ 4.6 (broad peak, 2H, NH2), 7.22 (single peak, 1H, H-5), 13.1 (broad peak, 1H, NH).
References
[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 12, p. 2794 - 2808
1H-PYRAZOLE-3-CARBONITRILE, 4-AMINO- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-PYRAZOLE-3-CARBONITRILE, 4-AMINO- Suppliers
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- Country
- India
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