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E3 ligase Ligand-Linker Conjugates 12

Product Name
E3 ligase Ligand-Linker Conjugates 12
CAS No.
1797406-80-4
Chemical Name
E3 ligase Ligand-Linker Conjugates 12
Synonyms
VH032-PEG3-N3;(S,R,S)-AHPC-PEG?-azide;(S,R,S)-AHPC-PEG3-azide;VHL Ligand-Linker Conjugates 8;(S,R,S)-AHPC-PEG3-N3 (VH032-PEG3-N3);E3 ligase Ligand-Linker Conjugates 12;(S,R,S) AHPC PEG3 N3,(S,R,S)-AHPC-PEG-3-N3,Inhibitor,inhibit,E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG3N3;L-Prolinamide, N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
CBNumber
CB24694700
Molecular Formula
C30H43N7O7S
Formula Weight
645.78
MOL File
1797406-80-4.mol
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E3 ligase Ligand-Linker Conjugates 12 Property

storage temp. 
2-8°C
form 
Oil
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
904651
Product name
(S,R,S)-AHPC-PEG3-azide
Purity
≥95%
Packaging
50mg
Price
$549
Updated
2024/03/01
Iris Biotech GmbH
Product number
PTC1610
Product name
(S,R,S)-AHPC-PEG3-N3
Packaging
50mg
Price
$634.5
Updated
2021/12/16
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E3 ligase Ligand-Linker Conjugates 12 Chemical Properties,Usage,Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG3-Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reaction type: click chemistry
reagent type: ligand-linker conjugate

E3 ligase Ligand-Linker Conjugates 12 Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 ligase Ligand-Linker Conjugates 12 Suppliers

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Sigma-Aldrich
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View Lastest Price from E3 ligase Ligand-Linker Conjugates 12 manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
(S,R,S)-AHPC-PEG3-azide 1797406-80-4
Price
US $0.00/mg
Min. Order
100mg
Purity
>99.00%
Supply Ability
100mg
Release date
2024-04-01

1797406-80-4, E3 ligase Ligand-Linker Conjugates 12Related Search:


  • E3 ligase Ligand-Linker Conjugates 12
  • (S,R,S)-AHPC-PEG3-azide
  • VH032-PEG3-N3
  • VHL Ligand-Linker Conjugates 8
  • (S,R,S) AHPC PEG3 N3,(S,R,S)-AHPC-PEG-3-N3,Inhibitor,inhibit,E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG3N3
  • (2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
  • (S,R,S)-AHPC-PEG?-azide
  • (2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
  • L-Prolinamide, N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
  • (S,R,S)-AHPC-PEG3-N3 (VH032-PEG3-N3)
  • 1797406-80-4