PYRAZINE N-OXIDE
- Product Name
- PYRAZINE N-OXIDE
- CAS No.
- 2423-65-6
- Chemical Name
- PYRAZINE N-OXIDE
- Synonyms
- Pyrazine-1-oxide;PYRAZINE N-OXIDE;RARECHEM BG FB 0041;1-oxidopyrazin-1-ium;Pyrazine N-oxide 97%;Pyrazine N-oxide
- CBNumber
- CB2470485
- Molecular Formula
- C4H4N2O
- Formula Weight
- 96.09
- MOL File
- 2423-65-6.mol
PYRAZINE N-OXIDE Property
- Melting point:
- 112-116 °C
- Boiling point:
- 126-127 °C(Press: 14 Torr)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 0.45±0.39(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- Hazard Codes
- F,Xn
- Risk Statements
- 11-22-37/38-41
- Safety Statements
- 26-39
- RIDADR
- UN 1325 4.1/PG 2
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H228Flammable solid
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 678260
- Product name
- Pyrazine N-oxide
- Purity
- 97%
- Packaging
- 5g
- Price
- $286
- Updated
- 2023/06/20
- Product number
- P841103
- Product name
- Pyrazine1-oxide
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- API0008547
- Product name
- PYRAZINE N-OXIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $665.44
- Updated
- 2021/12/16
- Product number
- API0008547
- Product name
- PYRAZINE N-OXIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1005.38
- Updated
- 2021/12/16
- Product number
- 1770AB
- Product name
- Pyrazine1-oxide
- Packaging
- 25g
- Price
- $1720
- Updated
- 2021/12/16
PYRAZINE N-OXIDE Chemical Properties,Usage,Production
Synthesis
290-37-9
2423-65-6
General procedure 1: Diazine oxidation; Pyrazine (1 eq.) and mCPBA (1 eq.) were dissolved in DCM (0.2 M). The reaction mixture was stirred at room temperature for 16 hours. PPh3 (0.5 eq.) was then added to quench the unreacted peracid and stirring was continued for 4 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure and the residue was purified by silica gel column chromatography. The synthesis of pyrazine-N-oxide was carried out according to the general procedure 1 using 100% EtOAc as the initial eluent, followed by switching to 20% MeOH/EtOAc mixed solvent in a gradient elution to give a white solid product in 88% yield. The product was characterized as follows: 1H NMR (300 MHz, CDCl3, 293 K, TMS): δ 8.50 (2H, d, J = 3.9 Hz), 8.14 (2H, d, J = 4.8 Hz); 13C NMR (75 MHz, CDCl3, 293 K, TMS): 147.8, 134.0; HRMS (ESI) m/z calculated for C4H4N2O [M]+: 96.0324, found: 96.0295; mp: 103.2-104.5 °C; IR (νmax/cm-1): 3120, 3088, 1595, 861, 847, 838; Rf (20% MeOH/EtOAc): 0.3.
Purification Methods
If the sample contains pyrazine-1-oxide, then place it in a Soxhlet extractor and extract it with hot pet ether (b 60-68o) in which the mono-oxide is soluble. Collect the dioxide from the thimble and recrystallise it from MeOH. It is dried in vacuo. It has at 1270cm-1 . [Koelsch & Gumprecht J Org Chem 23 1605 1958.]
References
[1] Organic Letters, 2017, vol. 19, # 18, p. 4707 - 4709
[2] Organic Letters, 2018, vol. 20, # 8, p. 2346 - 2350
[3] Angewandte Chemie - International Edition, 2006, vol. 45, # 46, p. 7781 - 7786
[4] Patent: US2008/132698, 2008, A1. Location in patent: Page/Page column 17-18
[5] Chemical Communications, 2015, vol. 51, # 12, p. 2425 - 2428
PYRAZINE N-OXIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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