ChemicalBook > CAS DataBase List > L-2,4-DICHLOROPHENYLALANINE

L-2,4-DICHLOROPHENYLALANINE

Product Name
L-2,4-DICHLOROPHENYLALANINE
CAS No.
111119-36-9
Chemical Name
L-2,4-DICHLOROPHENYLALANINE
Synonyms
L-2,4-DICHLOROPHE;H-PHE(2,4-DICL)-OH;H-PHE(2,4-CL 2)-OH;L-Phe(2,4-DiCl)-OH;RARECHEM BK PT 0109;H-L-PHE(2,4-CL2)-OH;2,4-Dichloro-phenyla;L-2,4-Dichloro-phe-OH;4-Dichloro-L-phenylalanine;L-2,4-DICHLOROPHENYLALANINE
CBNumber
CB2470728
Molecular Formula
C9H9Cl2NO2
Formula Weight
234.08
MOL File
111119-36-9.mol
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L-2,4-DICHLOROPHENYLALANINE Property

Melting point:
238-240 °C
Boiling point:
368.1±42.0 °C(Predicted)
Density 
1.450±0.06 g/cm3(Predicted)
storage temp. 
Store at 0-5°C
pka
2.14±0.15(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
111119-36-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D437935
Product name
2,4-Dichloro-L-phenylalanine
Packaging
250mg
Price
$55
Updated
2021/12/16
Usbiological
Product number
273909
Product name
L-2,4-Dichlorophenylalanine
Packaging
500mg
Price
$333
Updated
2021/12/16
Activate Scientific
Product number
AS88013
Product name
2,4-Dichloro-L-phenylalanine
Purity
95+% ee
Packaging
1g
Price
$33
Updated
2021/12/16
Chem-Impex
Product number
07432
Product name
L-2,4-Dichlorophenylalanine,≥99%(HPLC)
Purity
≥99%(HPLC)
Packaging
1G
Price
$58.24
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD49216
Product name
L-2,4-Dichlorophenylalanine
Packaging
500mg
Price
$60
Updated
2021/12/16
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L-2,4-DICHLOROPHENYLALANINE Chemical Properties,Usage,Production

Synthesis

1201-99-6

111119-36-9

General procedure for the synthesis of L-2,4-dichlorophenylalanine from 2,4-dichlorostyrenic acid: general method: suitable aldehydes (1j-1,1n or 1o, 0.5 mmol), malonic acid (1.0 mmol), and piperidine (0.01 mmol) were dissolved in DMSO (500 mL), and the mixture was placed in a microwave reactor and heated (60 °C, 30 min ). Upon completion of the reaction, it was cooled to room temperature and ammonia solution (9.5 mL, 13% w/v, ~7 M, adjusted to pH 10.0 by slow addition of dry ice cubes) was added, followed by addition of excess E. coli BL21 (DE3) cells (400 mg wet cell paste) to catalyze the production of the target product L-2,4-dichlorophenylalanine. The suspension was stirred at 37°C for several hours and the reaction progress was monitored by HPLC. For product isolation, the reaction mixture was acidified to pH <2.0 with aqueous H2SO4 (20% w/v) and centrifuged (8000 rpm, 5 min) to remove the cells and unconverted substrate precipitate. Dowex 50WX8 hydrogen-based resin (5.0 g) was loaded in a disposable plastic column and washed sequentially with deionized water (20 mL) and H2SO4 aqueous solution (20 mL, 5% w/v). The supernatant after biotransformation was upsampled to the resin column at a flow rate of 1 mL/min. The resin bed was first washed with deionized water until the effluent was neutral, and then the product was eluted with NH4OH aqueous solution (20 mL, 5% w/v). The product-containing eluates were combined and dried overnight in a centrifugal evaporator to give the L-phenylalanine derivative (L-3j-1, L-3n or L-3o) as a white solid.

References

[1] Tetrahedron, 2016, vol. 72, # 46, p. 7256 - 7262

L-2,4-DICHLOROPHENYLALANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L-2,4-DICHLOROPHENYLALANINE manufacturers

Career Henan Chemical Co
Product
L-2,4-DICHLOROPHENYLALANINE 111119-36-9
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

111119-36-9, L-2,4-DICHLOROPHENYLALANINERelated Search:

2,4-DIFLUORO-L-PHENYLALANINE 2,4-dinitro-3-phenyl-L-alanine L-2,4-DIMETHYLPHE D-3,4-DICHLOROPHENYLALANINE D-2,5-Dichlorophenylalanine N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-3,4-DICHLOROPHENYLALANINE,fluorenylmethoxycarbonyl-d-3,4-dichlorophenylalanine,FMOC-D-3,4-DICHLOROPHENYLALANINE L-2,4-DICHLOROPHENYLALANINE (R)-BOC-2,4-DICHLOROPHENYLALANINE,(S)-BOC-2,4-DICHLOROPHENYLALANINE,BOC-L-2,4-DICHLOROPHENYLALANINE,BOC-D-2,4-DICHLOROPHENYLALANINE D-2,4-DICHLOROPHENYLALANINE FMOC-3,4-DICHLORO-L-PHENYLALANINE BOC-L-3,4-Dichlorophe BOC-D-3,4-Dichlorophe FMOC-L-3,4-Dichlorophe L-3,4-DICHLOROPHENYLALANINE,DL-3,4-Dichlorophenylalanine 3,4-DICHLORO-DL-PHENYLALANINE L-3,4-DICHLOROPHENYLALANINE METHYL ESTER HYDROCHLORIDE DL-2,5-Dichlorophenylalanine L-2,6-Dichlorophenylalanine

  • L-2,4-DICHLOROPHE
  • L-2,4-DICHLOROPHENYLALANINE
  • H-PHE(2,4-CL 2)-OH
  • H-PHE(2,4-DICL)-OH
  • H-L-PHE(2,4-CL2)-OH
  • RARECHEM BK PT 0109
  • (S)-2-AMINO-3-(2,4-DICHLORO-PHENYL)-PROPIONIC ACID
  • 2,4-Dichloro-L-4-phenylalanine
  • (2S)-2-amino-3-(2,4-dichlorophenyl)propanoic acid
  • (S)-2-amino-3-(3,4-dichlorophenyl)propanoic acid
  • 2,4-Dichloro-phenyla
  • 4-Dichloro-L-phenylalanine
  • H-Phe(2,4-Cl2)-OH 2,4-Dichloro-L-Phenylalanine
  • (S)-2-AMino-3-(2,4-dichlorophenyl)propanoic acid
  • L-2,4-Dichloro-phe-OH
  • L-2,4-Dichlorophenylalanine99+%
  • L-Phe(2,4-DiCl)-OH
  • 2,4-DICHLORO-L-PHENYLALANINE
  • L-Phenylalanine, 2,4-dichloro-
  • (S)-2-Amino-3-(2,4-dichlorophenyl)propanoicaci
  • L-2,4-DICHLOROPHENYLALANINE USP/EP/BP
  • 111119-36-9
  • 11119-36-9
  • Phenylalanine analogs and other aromatic alpha amino acids
  • a-amino
  • Amino Acids