AT1

Product Name: AT1
CAS No.: 2098836-45-2
Chemical Name: AT1
Synonyms: BRD4 PROTAC AT1;L-Prolinamide, N-acetyl-3-[[6-[[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetyl]amino]hexyl]thio]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((R)-2-Acetamido-3-((6-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)hexyl)thio)-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-(2R)-2-Acetamido-3-[[6-[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamido]hexyl]thio]-3-methylbutanoyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl)pyrrolidinine-2-carboxamide;(2S,4R)-1-[(2R)-3-[(6-{2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,?]trideca-2(6),4,7,10,12-pentaen-9-yl]acetamido}hexyl)sulfanyl]-2-acetamido-3-methylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
CBNumber: CB24718703
Molecular Formula: C48H58ClN9O5S3
Formula Weight: 972.68
MOL File: 2098836-45-2.mol

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AT1 Property

Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (102.81 mM)
pka: 14.05±0.40(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3565
Product name: AT1
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $311.6
Updated: 2025/07/31

ChemScene

Product number: CS-0040740
Product name: BRD4degraderAT1
Purity: 98.76%
Packaging: 5mg
Price: $340
Updated: 2021/12/16

ChemScene

Product number: CS-0040740
Product name: BRD4degraderAT1
Purity: 98.76%
Packaging: 10mg
Price: $590
Updated: 2021/12/16

ChemScene

Product number: CS-0040740
Product name: BRD4degraderAT1
Purity: 98.76%
Packaging: 25mg
Price: $1200
Updated: 2021/12/16

ChemScene

Product number: CS-0040740
Product name: BRD4degraderAT1
Purity: 98.76%
Packaging: 50mg
Price: $2100
Updated: 2021/12/16

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AT1 Chemical Properties,Usage,Production

Uses

BRD4 degrader AT1 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 as a highly selective Brd4 degrader, with a Kd of 44 nM for Brd4BD2 in cells.

storage

Store at -20°C

References

[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329

AT1 Preparation Products And Raw materials

Raw materials

Preparation Products

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AT1 Suppliers

China 29 United Kingdom 1 United States 3 Global 33

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View Lastest Price from AT1 manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: BRD4 degrader AT1 2098836-45-2
Price: US $0.00/mg
Min. Order: 1mg
Purity: 98%min
Supply Ability: 50mg
Release date: 2021-08-26

2098836-45-2, AT1Related Search:

BRD4 PROTAC AT1

(2S,4R)-1-(2R)-2-Acetamido-3-[[6-[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamido]hexyl]thio]-3-methylbutanoyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl)pyrrolidinine-2-carboxamide

L-Prolinamide, N-acetyl-3-[[6-[[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetyl]amino]hexyl]thio]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

(2S,4R)-1-((R)-2-Acetamido-3-((6-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)hexyl)thio)-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

(2S,4R)-1-[(2R)-3-[(6-{2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,?]trideca-2(6),4,7,10,12-pentaen-9-yl]acetamido}hexyl)sulfanyl]-2-acetamido-3-methylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

2098836-45-2