TAS-115 Methanesulfonic acid salt

Product Name: TAS-115 Methanesulfonic acid salt
CAS No.: 1688673-09-7
Chemical Name: TAS-115 Methanesulfonic acid salt
Synonyms: TAS115;TAS 115;TAS-115 mesylate;Pamufetinib (mesylate);TAS-115 methanesulfonate;Pamufetinib (TAS-115) mesylate;TAS-115 Methanesulfonic acid salt;TAS-115 mesylate (TAS-115 methanesulfonate);TAS-115 mesylate (Synonyms: TAS-115 methanesulfonate)
CBNumber: CB24732343
Molecular Formula: C28H27FN4O7S2
Formula Weight: 614.66
MOL File: 1688673-09-7.mol

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TAS-115 Methanesulfonic acid salt Property

storage temp.: Store at -20°C
solubility: DMSO: slightly soluble; PBS (pH 7.2): slightly soluble; Water: slightly soluble
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0081113
Product name: TAS-115mesylate
Purity: 99.15%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0081113
Product name: TAS-115mesylate
Purity: 99.15%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0081113
Product name: TAS-115mesylate
Purity: 99.15%
Packaging: 50mg
Price: $900
Updated: 2021/12/16

ChemScene

Product number: CS-0081113
Product name: TAS-115mesylate
Purity: 99.15%
Packaging: 100mg
Price: $1500
Updated: 2021/12/16

DC Chemicals

Product number: DC12256
Product name: TAS-115mesylate(TAS-115methanesulfonate)
Purity: >98%
Packaging: 1g
Price: $3500
Updated: 2021/12/16

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TAS-115 Methanesulfonic acid salt Chemical Properties,Usage,Production

Uses

Pamufetinib (TAS-115) mesylate is a potent VEGFRand hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor, with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively.

in vivo

Pamufetinib mesylate completely suppresses the progression of MET-inactivated tumor by blocking angiogenesis without toxicity when given every day for 6 weeks, even at a serum-saturating dose of Pamufetinib mesylate. Pamufetinib mesylate induces marked tumor shrinkage and prolonges survival in MET-amplified human cancer–bearing mice^[1].

References

[1] Fujita H, et al. The novel VEGF receptor/MET-targeted kinase inhibitor TAS-115 has marked in vivo antitumor properties and a favorable tolerability profile. Mol Cancer Ther. 2013 Dec;12(12):2685-96. DOI:10.1158/1535-7163.MCT-13-0459
[2] Nakade J, et al. Triple inhibition of EGFR, Met, and VEGF suppresses regrowth of HGF-triggered, erlotinib-resistant lung cancer harboring an EGFR mutation. J Thorac Oncol. 2014 Jun;9(6):775-83. DOI:10.1097/JTO.0000000000000170

TAS-115 Methanesulfonic acid salt Preparation Products And Raw materials

Raw materials

Preparation Products

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TAS-115 Methanesulfonic acid salt Suppliers

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1688673-09-7, TAS-115 Methanesulfonic acid saltRelated Search:

TAS-115 Methanesulfonic acid salt

TAS-115 mesylate (Synonyms: TAS-115 methanesulfonate)

TAS115;TAS 115

TAS-115 mesylate

TAS-115 methanesulfonate

TAS-115 mesylate (TAS-115 methanesulfonate)

Pamufetinib (mesylate)

Pamufetinib (TAS-115) mesylate

1688673-09-7