N-Acetic acid-indole-3-carboxaldehyde
- Product Name
- N-Acetic acid-indole-3-carboxaldehyde
- CAS No.
- 138423-98-0
- Chemical Name
- N-Acetic acid-indole-3-carboxaldehyde
- Synonyms
- TIMTEC-BB SBB010076;CHEMBRDG-BB 4002661;3-FORMYL INDOLEACETIC ACID;3-FORMYLINDOLE-1-ACETIC ACID;3-Formylindole-N-acetic acid;3-Formylindol-1-yl-AceticAci;(3-FORMYL-1-INDOLYL)ACETIC ACID;3-FORMYLINDOLE-1-YL-ACETIC ACID;3-Formyl-1H-indole-1-acetic acid;(3-FORMYL-INDOL-1-YL)-ACETIC ACID
- CBNumber
- CB2476876
- Molecular Formula
- C11H9NO3
- Formula Weight
- 203.19
- MOL File
- 138423-98-0.mol
N-Acetic acid-indole-3-carboxaldehyde Property
- Melting point:
- 197-200 °C(lit.)
- Boiling point:
- 458.5±25.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- pka
- 4.15±0.10(Predicted)
- form
- solid
- Appearance
- Light yellow to yellow Solid
- Sensitive
- Air Sensitive
- BRN
- 5431204
- InChI
- InChI=1S/C11H9NO3/c13-7-8-5-12(6-11(14)15)10-4-2-1-3-9(8)10/h1-5,7H,6H2,(H,14,15)
- InChIKey
- ZUUGBTJTGRTIFK-UHFFFAOYSA-N
- SMILES
- N1(CC(O)=O)C2=C(C=CC=C2)C(C=O)=C1
- CAS DataBase Reference
- 138423-98-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 17028
- Product name
- (3-Formyl-1-indolyl)acetic acid
- Purity
- ≥97.0%
- Packaging
- 1g
- Price
- $74.8
- Updated
- 2023/06/20
- Product number
- F700418
- Product name
- (3-Formyl-1H-indol-1-yl)aceticAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 008422
- Product name
- (3-Formyl-indol-1-yl)-acetic acid
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- 008422
- Product name
- (3-Formyl-indol-1-yl)-acetic acid
- Packaging
- 5g
- Price
- $59
- Updated
- 2021/12/16
- Product number
- D187
- Product name
- (3-Formyl-indol-1-yl)-aceticacid
- Packaging
- 1g
- Price
- $73
- Updated
- 2021/12/16
N-Acetic acid-indole-3-carboxaldehyde Chemical Properties,Usage,Production
Chemical Properties
Solid
Uses
Handle to synthesize an indolecarboxaldehyde resin by coupling to an amino-resin. Amines and derivatives can be immobilized by reductive amination of this aldehyde resin. Mild cleavage with 50% TFA
reaction suitability
reagent type: cross-linking reagent
Synthesis
27065-94-7
138423-98-0
Ethyl (3-formyl-1H-indol-1-yl)acetate (15.9 g, 69 mmol) was dissolved in 1,4-dioxane (100 mL), 1 N sodium hydroxide solution (10 mL) was added, and the resulting mixture was stirred at 0 °C. The reaction mixture was then stirred at room temperature for 4 days. After completion of the reaction, water (500 mL) was added and the mixture was washed with ether (150 mL). The aqueous phase was acidified with 5 N hydrochloric acid to pH < 2 and subsequently extracted with ethyl acetate (250 mL + 150 mL) in two fractions. The organic phases were combined, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give (3-formylindol-1-yl)acetic acid (10.3 g, 73% yield) as a white solid. The product was characterized by 1H-NMR (DMSO-d6): δH=5.20 (2H, s), 7.3 (2H, m), 7.55 (1H, d), 8.12 (1H, d), 8.30 (1H, s), 9.95 (1H, s), 13.3 (1H, br s).
References
[1] Patent: WO2006/82245, 2006, A1. Location in patent: Page/Page column 230
[2] Patent: US2005/65066, 2005, A1. Location in patent: Page/Page column 120
[3] Patent: WO2004/80480, 2004, A1. Location in patent: Page/Page column 226
[4] Patent: WO2006/5683, 2006, A1. Location in patent: Page/Page column 225
[5] Patent: US2003/229120, 2003, A1. Location in patent: Page 75
N-Acetic acid-indole-3-carboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Acetic acid-indole-3-carboxaldehyde manufacturers
- Product
- N-Acetic acid-indole-3-carboxaldehyde 138423-98-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-02