TRANS-3-BROMO-N-ETHYLCINNAMAMIDE

Product Name: TRANS-3-BROMO-N-ETHYLCINNAMAMIDE
CAS No.: 58473-74-8
Chemical Name: TRANS-3-BROMO-N-ETHYLCINNAMAMIDE
Synonyms: D03513;cinromide;Cinromide (usan/inn);LABOTEST-BB LT00453193;m-Bromo-N-ethylcinnamamide;trans-m-Bromo-N-ethylcinnamamide;TRANS-3-BROMO-N-ETHYLCINNAMAMIDE;3-(3-Bromophenyl)-N-ethylacrylamide;(E)-3-(3-Bromophenyl)-N-ethylacrylamide;(e)-3-(3-bromophenyl)-n-ethyl-2-propenamide
CBNumber: CB2477363
Molecular Formula: C11H12BrNO
Formula Weight: 254.12
MOL File: 58473-74-8.mol

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TRANS-3-BROMO-N-ETHYLCINNAMAMIDE Property

Melting point:: 89-91 °C(lit.)
Boiling point:: 417.5±45.0 °C(Predicted)
Density: 1.369±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 14.59±0.46(Predicted)
color: Pale Beige
Merck: 13,2334

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 2
RTECS: UC6314000
Toxicity: LD50 in mice (mg/kg): 660 ±28 i.p.; 2277 ±250 orally (Soroko)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C596463
Product name: Cinromide
Packaging: 10g
Price: $1015
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0067455
Product name: TRANS-3-BROMO-N-ETHYLCINNAMAMIDE
Purity: 95.00%
Packaging: 10G
Price: $1138.57
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0067455
Product name: TRANS-3-BROMO-N-ETHYLCINNAMAMIDE
Purity: 95.00%
Packaging: 1G
Price: $626.08
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0067455
Product name: TRANS-3-BROMO-N-ETHYLCINNAMAMIDE
Purity: 95.00%
Packaging: 250MG
Price: $682.78
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0067455
Product name: TRANS-3-BROMO-N-ETHYLCINNAMAMIDE
Purity: 95.00%
Packaging: 5G
Price: $818.85
Updated: 2021/12/16

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TRANS-3-BROMO-N-ETHYLCINNAMAMIDE Chemical Properties,Usage,Production

Originator

Cinromide,ZYF Pharm Chemical

Uses

bone resorption inhibitor, farnesyldiphosphate synthetase inhibitor, antimetastatic

Uses

Cinromide is an anticonvulsant.

Definition

ChEBI: Cinromide is a member of cinnamamides and a secondary carboxamide.

Manufacturing Process

3-Bromo-N-ethylcinnamamide: I). A solution of trans-3-bromocinnamoyl chloride (12.3 g) in anhydrous toluene (150 ml) was added slowly with stirring to a solution of ethylamine (10 g) in dry ether (100 ml) at room temperature. The reaction mixture was heated at reflux for 1 hour, and the solvent and excess amine were then removed under reduced pressure. The residue was triturated with water, filtered, and recrystallized from ethanol-water to give trans-3-bromo-Nethylcinnamamide, m.p. 89-90°C, as a white crystalline material. NMR and IR spectra as well as elemental analysis were consistent with the assigned
II). trans-m-Bromocinnamic acid (14.8 g), ethanol (173 ml) and concentrated sulfuric acid (0.4 ml) were combined and heated at reflux for 15 hours. About 150 ml of the ethanol was distilled off, and the remaining solution was poured into ice/water (140 ml). The cold mixture was made strongly alkaline with 40% sodium hydroxide and extracted with methylene chloride (4x60 ml). The combined methylene chloride extract was dried over anhydrous potassium carbonate. The potassium carbonate was removed by filtration and the solvent stripped off under reduced pressure. trans-ethyl-3-Bromocinnamate, was obtained as a partially solidified oil. (IR spectrum was consistent with this compound).
trans-Ethyl-3-bromocinnamate (8.4 g), ethylamine (6.7 g), methanol (18 ml) and 4A molecular sieves (1 g) were combined and heated at reflux for ? hour. The mixture was cooled to about 45°C and sodium methylate (0.6 g) added. The mixture was then heated at reflux 1? hour and then cooled. It was acidified with concentrated hydrochloric acid (12 ml). The sieves were removed by filtration. Ice water was added to the filtrate to precipitate trans 3-bromo-N-ethylcinnamamide, m.p. 89-90°C (after recrystallization from ethanol/water)

Therapeutic Function

Anticonvulsant, Antiepileptic

TRANS-3-BROMO-N-ETHYLCINNAMAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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TRANS-3-BROMO-N-ETHYLCINNAMAMIDE Suppliers

China 28 Germany 1 India 1 Switzerland 1 United States 6 Global 37

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58473-74-8, TRANS-3-BROMO-N-ETHYLCINNAMAMIDERelated Search:

TRANS-3-BROMO-N-ETHYLCINNAMAMIDE 5-((3-BROMO-4-METHOXYPHENYL)METHYLENE)-3-PROP-2-ENYL-2-THIOXO-1,3-THIAZOLIDIN-4-ONE N-BENZYL-3-(3-BROMOPHENYL)ACRYLAMIDE 3-(3-BROMOPHENYL)-N-CYCLOPROPYLACRYLAMIDE 4-[5-(3-BROMO-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID AURORA 9922 4-((4-[(5Z)-5-(3-BROMOBENZYLIDENE)-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BUTANOYL)AMINO)BENZOIC ACID AKOS BBS-00007550 AURORA 2281 6-[5-(3-BROMO-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-HEXANOIC ACID SALOR-INT L333697-1EA AURORA 4774 AURORA 22381 N-BENZYL-2-[(5Z)-5-(3-BROMOBENZYLIDENE)-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]-N-(2-HYDROXYETHYL)ACETAMIDE AURORA 5199 AURORA 9547 3-[5-(3-BROMO-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-PROPIONIC ACID 5-[(5-BROMO-2-ETHOXYPHENYL)METHYLENE]-3-(3-PYRIDINYLMETHYL)-2-THIOXOTETRAHYDRO-4H-IMIDAZOL-4-ONE

TRANS-3-BROMO-N-ETHYLCINNAMAMIDE

(e)-3-(3-bromophenyl)-n-ethyl-2-propenamide

cinromide

TRANS-3-BROMO-N-ETHYLCINNAMAMIDE, TECH., 90%

LABOTEST-BB LT00453193

m-Bromo-N-ethylcinnamamide

Cinromide (usan/inn)

D03513

trans-m-Bromo-N-ethylcinnamamide

3-(3-Bromophenyl)-N-ethylacrylamide

2-Propenamide, 3-(3-bromophenyl)-N-ethyl-, (2E)-

(E)-3-(3-Bromophenyl)-N-ethylacrylamide

metabolic,acid,transporter,Inhibitor,anticonvulsant,amino,neutral,inhibit,Cinromide

58473-74-8

BrC6H4CHCHCONHC2H5

AMINE

Amides

Building Blocks

Carbonyl Compounds

Organic Building Blocks

FOSAMAX

Amides

Carbonyl Compounds