FR183998 free base
- Product Name
- FR183998 free base
- CAS No.
- 239440-20-1
- Chemical Name
- FR183998 free base
- Synonyms
- FR183998;FR183998 free base;FR-183998 free base,FR183998 free base;1,3-Benzenedicarboxamide, N1-(aminoiminomethyl)-5-(2,5-dichloro-3-thienyl)-N3-[2-(dimethylamino)ethyl]-
- CBNumber
- CB24797058
- Molecular Formula
- C17H19Cl2N5O2S
- Formula Weight
- 428.34
- MOL File
- 239440-20-1.mol
FR183998 free base Property
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 11.35±0.46(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CSN21301
- Product name
- FR183998
- Packaging
- 5mg
- Price
- $1202
- Updated
- 2021/12/16
- Product number
- CSN21301
- Product name
- FR183998
- Packaging
- 10mg
- Price
- $1923
- Updated
- 2021/12/16
FR183998 free base Chemical Properties,Usage,Production
Uses
FR183998, is a potent Na+/H+-exchange inhibitor.
in vivo
FR183998 (0.1 and 1.0 mg/kg, i.v.) shows no effect hemodynamic parameters, and does not affect mean blood pressure and heart rate in conscious rats. Pretreatment of 0.01, 0.032, 0.10 mg/kg FR183998 or posttreament of 0.032 and 0.10 mg/kg FR183998 via intravenous administration, dose-dependently reuces reperfusion-induced ventricular fibrillation (VF) and mortality in reperfusion-induced arrhythmias in anesthetized rats, with ED50s against VF of 0.015 mg/kg and 0.070 mg/kg, respectively. FR183998 also reduces myocardial infarct sizes, and suppresses the arrhythmias in anesthetized rats[1]. FR183998 (1 mg/kg, i.v.) reduces the increase in serum levels of alanine transaminase, aspartate transaminase, and lactate dehydrogenase induced by hepatic I/R, and prevents the incidences of hepatic necrosis, apoptosis, and neutrophil infiltration. FR183998 blocks the I/R-induced activation of the NF-κB, reduces induction of iNOS and inhibits the production of nitric oxide. FR183998 also decreases the expression of the iNOS gene antisense transcript in the liver of hepatic I/R rats[2].
FR183998 free base Preparation Products And Raw materials
Raw materials
Preparation Products
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