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FR183998 free base

Product Name
FR183998 free base
CAS No.
239440-20-1
Chemical Name
FR183998 free base
Synonyms
FR183998;FR183998 free base;FR-183998 free base,FR183998 free base;1,3-Benzenedicarboxamide, N1-(aminoiminomethyl)-5-(2,5-dichloro-3-thienyl)-N3-[2-(dimethylamino)ethyl]-
CBNumber
CB24797058
Molecular Formula
C17H19Cl2N5O2S
Formula Weight
428.34
MOL File
239440-20-1.mol
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FR183998 free base Property

Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
11.35±0.46(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

CSNpharm
Product number
CSN21301
Product name
FR183998
Packaging
5mg
Price
$1202
Updated
2021/12/16
CSNpharm
Product number
CSN21301
Product name
FR183998
Packaging
10mg
Price
$1923
Updated
2021/12/16
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FR183998 free base Chemical Properties,Usage,Production

Uses

FR183998, is a potent Na+/H+-exchange inhibitor.

in vivo

FR183998 (0.1 and 1.0 mg/kg, i.v.) shows no effect hemodynamic parameters, and does not affect mean blood pressure and heart rate in conscious rats. Pretreatment of 0.01, 0.032, 0.10 mg/kg FR183998 or posttreament of 0.032 and 0.10 mg/kg FR183998 via intravenous administration, dose-dependently reuces reperfusion-induced ventricular fibrillation (VF) and mortality in reperfusion-induced arrhythmias in anesthetized rats, with ED50s against VF of 0.015 mg/kg and 0.070 mg/kg, respectively. FR183998 also reduces myocardial infarct sizes, and suppresses the arrhythmias in anesthetized rats[1]. FR183998 (1 mg/kg, i.v.) reduces the increase in serum levels of alanine transaminase, aspartate transaminase, and lactate dehydrogenase induced by hepatic I/R, and prevents the incidences of hepatic necrosis, apoptosis, and neutrophil infiltration. FR183998 blocks the I/R-induced activation of the NF-κB, reduces induction of iNOS and inhibits the production of nitric oxide. FR183998 also decreases the expression of the iNOS gene antisense transcript in the liver of hepatic I/R rats[2].

FR183998 free base Preparation Products And Raw materials

Raw materials

Preparation Products

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FR183998 free base Suppliers

China 14 United States 3 Global 17
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
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MedChemExpress
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Fax
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
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239440-20-1, FR183998 free baseRelated Search:


  • FR183998 free base
  • 1,3-Benzenedicarboxamide, N1-(aminoiminomethyl)-5-(2,5-dichloro-3-thienyl)-N3-[2-(dimethylamino)ethyl]-
  • FR-183998 free base,FR183998 free base
  • FR183998
  • 239440-20-1