MDL 19301
- Product Name
- MDL 19301
- CAS No.
- 89388-38-5
- Chemical Name
- MDL 19301
- Synonyms
- MDL 19301;Benzenamine, N-1,3-dithiolan-2-ylidene-4-hexyl-
- CBNumber
- CB24797083
- Molecular Formula
- C15H21NS2
- Formula Weight
- 279.46
- MOL File
- 89388-38-5.mol
MDL 19301 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
N-Bromosuccinimide Price
- Product number
- M199850
- Product name
- MDL19301
- Packaging
- 1mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- M199850
- Product name
- MDL19301
- Packaging
- 10mg
- Price
- $1470
- Updated
- 2021/12/16
MDL 19301 Chemical Properties,Usage,Production
Uses
MDL 19301, is a nonsteroidal, anti-inflammatory agent.
in vivo
Oral administration of MDL 19301 inhibits rat paw edema induced by carrageenan (ED30=4.8 mg/kg) or an Arthus reaction (ED30=8.2 mg/kg p.o.). The oral dose which induces gastric ulceration in 50% of fasted rats is greater than 1,000 mg/kg, demonstrating a more favorable therapeutic ratio than conventional nonsteroidal anti‐inflammatory agents. The anti-inflammatory activity of MDL 19301, but not that of MDL 16,861, is attenuated by co-administration of an inhibitor of drug metabolite (SKF525A). This suggests that MDL 19301 is a prodrug of MDL 16,861 and this phenomenon would explain its lack of ulcerogenicity. Additional anti-inflammatory properties of MDL 19301 include inhibition of carrageenan pleurisy, adjuvant arthritis, and HOAc-induced writhing. Other pharmacological data indicate that MDL 19301 administration results in inhibition of prostaglandin synthesis; inhibition of arachidonic acid-induced, but not prostaglandin-E2-induced, diarrhea in mice; and inhibition of ex vivo arachidonic-acid-induced, but not ADP-induced, rat platelet aggregation. MDL 19301 and MDL 16,861 are unexpectedly weak antipyretic agents in rats[1].
MDL 19301 Preparation Products And Raw materials
Raw materials
Preparation Products
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