ChemicalBook > CAS DataBase List > UT-155

UT-155

Product Name: UT-155
CAS No.: 2031161-35-8
Chemical Name: UT-155
Synonyms: UT-155;UT-155, 10 mM in DMSO;UT-155,Inhibitor,UT155,inhibit,Androgen Receptor,UT 155;(S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(5-fluoro-1H-indol-1-yl)-2-hydroxy-2-methylpropanamide;1H-Indole-1-propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-5-fluoro-α-hydroxy-α-methyl-, (αS)-
CBNumber: CB24797104
Molecular Formula: C20H15F4N3O2
Formula Weight: 405.35
MOL File: 2031161-35-8.mol

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UT-155 Property

Boiling point:: 613.6±55.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);246.7(Max Conc. mM)
pka: 12.74±0.29(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1/C20H15F4N3O2/c1-19(29,11-27-7-6-12-8-14(21)3-5-17(12)27)18(28)26-15-4-2-13(10-25)16(9-15)20(22,23)24/h2-9,29H,11H2,1H3,(H,26,28)/t19-/s3
InChIKey: CFSAYQVTXBMPRF-DETXXQSHNA-N
SMILES: C(N1C=CC2=CC(F)=CC=C12)[C@@](O)(C)C(=O)NC1C=CC(C#N)=C(C(F)(F)F)C=1 |&1:11,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb573218
Product name: UT-155
Packaging: 100mg
Price: $1802
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573218
Product name: UT-155
Packaging: 250mg
Price: $3580.2
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573218
Product name: UT-155
Packaging: 1g
Price: $7136.6
Updated: 2021/12/16

DC Chemicals

Product number: DC12102
Product name: UT-155
Purity: >98%
Packaging: 1g
Price: $2500
Updated: 2021/12/16

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UT-155 Chemical Properties,Usage,Production

Uses

UT-155 is a selective and potent androgen receptor (AR) antagonist, with a Ki of 267 nM for UT-155 binding to AR-LBD.

in vivo

Consistent with the anti-proliferative effects in vitro, UT-155 significantly inhibits the growth of 22RV1 xenograft by 53%, while, as expected, enzalutamide has no effect on the growth of the 22RV1 tumors. Tumor weights and PSA and the expression of AR and AR-SV are significantly lower in UT-155-treated animals^[1].

References

[1] Ponnusamy S, et al. Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer. Cancer Res. 2017 Nov 15;77(22):6282-6298. DOI:10.1158/0008-5472.CAN-17-0976

UT-155 Preparation Products And Raw materials

Raw materials

Preparation Products

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2031161-35-8, UT-155Related Search:

UT-155

1H-Indole-1-propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-5-fluoro-α-hydroxy-α-methyl-, (αS)-

UT-155,Inhibitor,UT155,inhibit,Androgen Receptor,UT 155

UT-155, 10 mM in DMSO

(S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(5-fluoro-1H-indol-1-yl)-2-hydroxy-2-methylpropanamide

2031161-35-8

2031131-35-8